Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7298 - 7310
Published: Oct. 8, 2024
Despite
the
increasing
interest
in
cellulose-derived
materials
biomedical
research,
there
remains
a
significant
gap
comprehensive
vivo
analyses
of
cellulosic
obtained
from
various
sources
and
processing
methods.
To
explore
durable
alternatives
to
synthetic
medical
meshes,
we
evaluated
biocompatibility
bacterial
nanocellulose,
regenerated
cellulose,
cellulose
nanofibrils
subcutaneous
transplantation
model,
alongside
incumbent
polypropylene
polydioxanone.
Notably,
this
study
demonstrates
through
alkali
dissolution
subsequent
regeneration.
All
implants
triggered
expected
foreign
body
response
host
tissue,
characterized
predominantly
by
macrophages
giant
cells.
Porous
promoted
cell
ingrowth
biointegration.
Our
results
highlight
potential
nanocellulose
as
safe
commercial
meshes.
However,
fragmentation
observed
for
nanofibril
meshes
suggests
need
measures
optimize
their
preparation.
Processes,
Journal Year:
2025,
Volume and Issue:
13(3), P. 790 - 790
Published: March 8, 2025
The
outstanding
properties
of
nanocellulose
have
led
to
a
wide
range
applications
in
packaging,
construction,
medicine,
electronics,
cosmetics,
environmental
solutions,
and
the
food
industry.
Specifically,
cellulose
nanocrystals
(CNC)
demonstrated
excellent
biocompatibility,
adaptable
surface
chemistry,
low
density,
optical
capabilities,
biodegradability,
renewability,
good
mechanical
properties.
However,
these
unique
characteristics
depend
on
raw
material,
processing,
post-treatment.
New
opportunities
CNC
production
are
being
explored
based
unconventional
resources
new,
environmentally
friendly
processes
replace
highly
polluting
inefficient
conventional
methods.
This
review
evaluated
current
methods
for
obtaining
from
green
processes,
focusing
organic
acids,
enzymes,
mechanical,
oxidative,
radiation-based
Gels,
Journal Year:
2025,
Volume and Issue:
11(1), P. 37 - 37
Published: Jan. 4, 2025
Cellulose
nanofibers
gained
increasing
interest
in
the
production
of
medical
devices
such
as
mucoadhesive
nanohydrogels
due
to
their
ability
retain
moisture
(high
hydrophilicity),
flexibility,
superior
porosity
and
durability,
biodegradability,
non-toxicity,
biocompatibility.
In
this
work,
we
aimed
compare
suitability
selected
bacterial
vegetal
nanocellulose
form
hydrogels
for
biomedical
applications.
The
cellulose
were
synthesized
from
brewer's
spent
grains
(BSG)
kombucha
membranes,
respectively.
Two
prepared,
one
based
on
other
(VNC
BNC,
respectively).
VNC
was
less
opaque
more
fluid
than
BNC.
cytocompatibility
vitro
antioxidant
activity
nanocellulose-based
investigated
using
human
gingival
fibroblasts
(HGF-1,
ATCC
CRL-2014).
investigation
hydrogel-mucin
interaction
revealed
that
BNC
hydrogel
had
an
approx.
2×
higher
mucin
binding
efficiency
at
a
hydrogel/mucin
ratio
(mg/mg)
=
4.
exhibited
highest
potential
increase
number
metabolically
active
viable
cells
(107.60
±
0.98%
cytotoxicity
negative
control)
among
all
culture
conditions.
reduced
amount
reactive
oxygen
species
(ROS)
by
about
23%
(105.5
2.2%
C-)
comparison
with
positive
control,
whereas
ROS
level
slightly
(120.2
3.9%
following
treatment.
Neither
two
showed
antibacterial
when
assessed
diffusion
method.
data
suggest
fermentation
could
be
better
candidate
cytocompatible
nanoformulations
grains.
both
VNC,
respectively,
should
improved.
