Versatile and Controlled Synthesis of Degradable, Water-Soluble Bottlebrush Polymers with Poly(disulfide) Backbones Derived from α-Lipoic Acid

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 207 - 213

Published: Feb. 3, 2025

Bottlebrush (BB) polymers, with their densely grafted side chains and unique architecture, are highly advantageous for drug delivery due to high functional group density conjugation, unimolecular nature, enhanced biodistribution properties. These attributes enable extended blood circulation half-life, improved tumor tissue penetration, tumoral accumulation. However, the typically nondegradable, all-carbon backbones of most BB polymers limit suitability applications requiring controlled clearance biodegradability. To address this, we developed degradable poly(disulfide) synthesized via reversible addition–fragmentation chain transfer (RAFT) copolymerization α-lipoic acid (LA), a renewable readily available compound, acrylate-based inimers. copolymers feature initiating sites subsequent synthesis. Using an atom radical polymerization (ATRP) grafting-from methodology, relatively low dispersities (Đ = 1.30–1.53), backbone degrees (DPbb), molar masses (Mn,MALS 650–2700 kg/mol). The easily cleavable disulfide bonds enabled degradation under mild reducing conditions. Beyond hydrophilic tri(ethylene glycol) methyl ether acrylate (TEGA) chains, cationic, anionic, zwitterionic demonstrating broad monomer compatibility. This scalable approach produces water-soluble, tunable architectures predictable molecular weights. By addressing need degradability in this work advances potential delivery, offering functionality, biocompatibility, sustainability.

Language: Английский

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Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.

Language: Английский

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Redox-Responsive Cross-Linking of Polycarbonate Nanomedicines for Enhanced Stability and Controlled Drug Delivery

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Self-assembled polymeric micelles formed from amphiphilic block copolymers offer a promising strategy for enhanced drug delivery due to their biocompatibility and controlled release. However, challenges such as poor colloidal stability under diluted conditions degradation during storage circulation limit further applications. To address these issues, we developed straightforward method constructing cross-linked polycarbonate that enhance while allowing stimuli-responsive delivery. By utilizing disulfide-based cross-linking covalent conjugation of the anticancer drug, our approach maintains micelle integrity extremely high loading over extended periods well superior control triggered release compared non-cross-linked versions, demonstrating in complex biological environments improved efficacy, presenting novel platform stable polymer-drug conjugate nanocarriers, holding significant therapeutic potential targeted cancer treatment.

Language: Английский

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Preparation and evaluation of a novel albumin-binding heterodimer therapeutic radiopharmaceutical with remarkable tumor accumulation and retention

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117589 - 117589

Published: April 1, 2025

Language: Английский

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Spontaneous assembly of a class of small molecule prodrugs directed by SN38

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(39), P. 9921 - 9929

Published: Jan. 1, 2024

Conjugating SN38 with small hydrophilic molecules via a biodegradable linker results in molecule self-assembling prodrugs that form well-defined nanofibers varying surface charges water.

Language: Английский

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