Composite materials for multimodal sonodynamic therapy in biomedical applications DOI Creative Commons

Min Ma,

Lili Luo,

Yuxuan Ding

et al.

Next Materials, Journal Year: 2024, Volume and Issue: 6, P. 100442 - 100442

Published: Dec. 3, 2024

Language: Английский

Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
Nanosensitizer-assisted sonodynamic therapy for breast cancer DOI Creative Commons

Jing Yu,

Jun-Rui Hu,

Yi Tian

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

Abstract Breast cancer is the most commonly diagnosed worldwide. Despite advancements in therapeutic modalities, its prognosis remains poor owing to complex clinical, pathological, and molecular characteristics. Sonodynamic therapy (SDT) a promising approach for tumor elimination, using sonosensitizers that preferentially accumulate tissues are activated by low-intensity ultrasound produce reactive oxygen species. However, clinical translation of SDT faces challenges, including limited efficiency resistance posed microenvironment. The emergence nanomedicine offers innovative strategies address these obstacles. This review discusses enhancing efficacy sonosensitizers, rational structural modifications, improved tumor-targeted enrichment, microenvironment remodeling, imaging-guided therapy. Additionally, SDT-based multimodal therapies, such as sono-chemotherapy, sono-immunotherapy, sono-photodynamic therapy, their potential applications breast treatment summarized. underlying mechanisms briefly outlined. Finally, this highlights current challenges prospects SDT, providing insights into future may improve outcomes cancer. Graphical abstract

Language: Английский

Citations

0
Mesoporous polydopamine (MPDA)-based drug delivery system for oral chemo-photothermal combinational therapy of orthotopic colon cancer DOI

Donghao Gu,

Yun Liu,

Liu L

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136618 - 136618

Published: Oct. 16, 2024

Language: Английский

Citations

2
Composite materials for multimodal sonodynamic therapy in biomedical applications DOI Creative Commons

Min Ma,

Lili Luo,

Yuxuan Ding

et al.

Next Materials, Journal Year: 2024, Volume and Issue: 6, P. 100442 - 100442

Published: Dec. 3, 2024

Language: Английский

Citations

1