A Carbon Nanotube/Pyrrolidonecarboxylic Acid Zinc Sponge for programmed management of Diabetic Wounds: Hemostatic, Antibacterial, Anti-inflammatory, and Healing Properties DOI Creative Commons
Chenwei Wu,

Liu Bo,

Qiulan Wen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101769 - 101769

Published: April 12, 2025

Wound healing in patients with diabetes is challenging because of chronic inflammation, inadequate vascularization, and susceptibility to infection. Current wound dressings often target specific stages lack comprehensive therapeutic approaches. This study introduces a novel approach using photodetachable sponge scaffold incorporating carbon nanotubes (CNTs), known for their high photothermal conversion efficiency, electrical conductivity, water absorption properties. The incorporated pyrrolidonecarboxylic acid zinc (PC1Z2), compound anti-inflammatory moisturizing properties, which was cross-linked within network CNTs decellularized dermal matrix. resulting shape-memory actively interfaces endogenous electric fields, facilitating signal transmission skin cells accelerating tissue repair. Upon exposure near-infrared (NIR) light, the PC1Z2 enhanced antibacterial efficacy (98 %) through conversion, promoting metabolism at site. Notably, absorbed exudates gradually released Zn2+, effectively reducing inflammation mice. In diabetic rat model, exudates, reduced accelerated granulation formation, angiogenesis, re-epithelialization. innovative dressing shows promise enhancing wounds.

Language: Английский

Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice DOI
Yufei Tang, Shuqi Feng, Keyi Yao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123083 - 123083

Published: Jan. 5, 2025

Language: Английский

Citations

0
An Integrated Janus Bioelectronic Bandage for Unidirectional Pumping and Monitoring of Wound Exudate DOI
Jing Wang,

Jin-Tao Ye,

Zhuoheng Li

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Single-functional wound dressings provide limited therapeutic benefits for chronic healing. Effective care wounds requires a multifunction that integrates exudate management, treatment, and continuous monitoring. Here, we introduce an integrated Janus bioelectronic bandage designed to achieve self-pumping management via electrospinning dressing with opposite wettability, antibacterial properties through silver nanoparticles (AgNPs), the monitoring of multiplex biomarkers in electrochemical sensors positioned on drainage side. The limits detection (LOD) are 0.15 mM glucose, 6.85 μM UA, 60.76 mV/decade pH (4–8), respectively. We demonstrated mice full-thickness models this effectively promoted healing, achieving closure rate 90.35% day 14, monitored dynamic changes three within situ over period 3 days.

Language: Английский

Citations

0
A Carbon Nanotube/Pyrrolidonecarboxylic Acid Zinc Sponge for programmed management of Diabetic Wounds: Hemostatic, Antibacterial, Anti-inflammatory, and Healing Properties DOI Creative Commons
Chenwei Wu,

Liu Bo,

Qiulan Wen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101769 - 101769

Published: April 12, 2025

Wound healing in patients with diabetes is challenging because of chronic inflammation, inadequate vascularization, and susceptibility to infection. Current wound dressings often target specific stages lack comprehensive therapeutic approaches. This study introduces a novel approach using photodetachable sponge scaffold incorporating carbon nanotubes (CNTs), known for their high photothermal conversion efficiency, electrical conductivity, water absorption properties. The incorporated pyrrolidonecarboxylic acid zinc (PC1Z2), compound anti-inflammatory moisturizing properties, which was cross-linked within network CNTs decellularized dermal matrix. resulting shape-memory actively interfaces endogenous electric fields, facilitating signal transmission skin cells accelerating tissue repair. Upon exposure near-infrared (NIR) light, the PC1Z2 enhanced antibacterial efficacy (98 %) through conversion, promoting metabolism at site. Notably, absorbed exudates gradually released Zn2+, effectively reducing inflammation mice. In diabetic rat model, exudates, reduced accelerated granulation formation, angiogenesis, re-epithelialization. innovative dressing shows promise enhancing wounds.

Language: Английский

Citations

0