Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers DOI Creative Commons
Fang Liu, Yongcheng Chen, Yue Huang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 18, 2024

Fungi are very common infectious pathogens, which may cause invasive and potentially life-threatening infections. However, the efficacy of antifungal medications remains limited. Herein, a Cu2+-phenolic nanoflower is designed to combat fungal infections by combining cuproptosis cell wall digestion. Firstly, protocatechuic acid (PA)-Cu2+ (PC) nanopetals prepared coordination interaction. Lywallzyme (Lyw) then added induce self-assembly PC form Lyw loaded (PCW) nanoflowers. PCW nanoflowers can effectively adhere surface digest walls facilitate Cu2+ penetrate into interior, thereby exerting synergistic fungicidal effect. exhibit excellent activity even in protein-rich high-salt conditions, where dissociative completely loses activity. Transcriptome sequencing analysis reveals that lead cuproptosis. The vivo effect confirmed on murine skin infection model keratitis model. Fungal be debilitating life-threatening. Here, authors report strategy combination digestion using lywallzyme-assembled copper-phenolic demonstrating effects models.

Language: Английский

Fungal detection and elimination based on AIEgens DOI
Pu Chen, Jiawen Zhao, Dong‐Mi Li

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216548 - 216548

Published: Feb. 26, 2025

Language: Английский

Citations

2
Polymer‐Mediated Delivery of Amphotericin B for Fungal Infections DOI Open Access

Yongnan Chen,

Fang Liu, Qiao Jin

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Invasive fungal infections have been an increasingly global issue with high mortality. Amphotericin B (AmB), as the “gold standard” antifungal drug, has broad‐spectrum activity and low clinical resistance. Therefore, AmB is most commonly used polyene antibiotic for treatment of invasive infections. However, serious side effects well bioavailability strongly restrict its applications. Polymer, diversified molecular design, widely in drug delivery form polymeric prodrugs, nanoparticles, hydrogels, etc. polymers hold great promise treating This review summarizes recent advances polymer‐based systems infections, including polymer‐AmB conjugates, nanotechnology‐based systems, microneedles. Taking advantage strategies, special attention paid to reducing improving safe effective therapy. Finally, limitations possible future directions are discussed.

Language: Английский

Citations

0
Nanoparticle-based antifungal therapies innovations mechanisms and future prospects DOI Creative Commons

Qinglin Wu,

Fulan Cen,

Ying Xie

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19199 - e19199

Published: April 8, 2025

Fungal infections present an increasing global health challenge, with a substantial annual mortality rate of 1.6 million deaths each year in certain situations. The emergence antifungal resistance has further complicated treatment strategies, underscoring the urgent need for novel therapeutic approaches. This review explores recent advances nanoparticle-based therapies targeting fungal infections, emphasizing their unique potential to enhance drug solubility, bioavailability, and targeted delivery. Nanoparticles offer ability penetrate biological barriers, improve stability, act as direct agents by disrupting cell walls generating reactive oxygen species. Despite promising applications, challenges such toxicity, scalability production, controlled release remain. Future research should focus on optimizing nanoparticle properties, evaluating long-term safety profiles, developing environmentally sustainable synthesis methods, exploring synergistic approaches existing drugs. Nanotechnology offers transformative opportunity management diseases, paving way more effective treatments.

Language: Английский

Citations

0
Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers DOI Creative Commons
Fang Liu, Yongcheng Chen, Yue Huang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 18, 2024

Fungi are very common infectious pathogens, which may cause invasive and potentially life-threatening infections. However, the efficacy of antifungal medications remains limited. Herein, a Cu2+-phenolic nanoflower is designed to combat fungal infections by combining cuproptosis cell wall digestion. Firstly, protocatechuic acid (PA)-Cu2+ (PC) nanopetals prepared coordination interaction. Lywallzyme (Lyw) then added induce self-assembly PC form Lyw loaded (PCW) nanoflowers. PCW nanoflowers can effectively adhere surface digest walls facilitate Cu2+ penetrate into interior, thereby exerting synergistic fungicidal effect. exhibit excellent activity even in protein-rich high-salt conditions, where dissociative completely loses activity. Transcriptome sequencing analysis reveals that lead cuproptosis. The vivo effect confirmed on murine skin infection model keratitis model. Fungal be debilitating life-threatening. Here, authors report strategy combination digestion using lywallzyme-assembled copper-phenolic demonstrating effects models.

Language: Английский

Citations

3