Focus on therapeutic peptides and their delivery DOI Creative Commons

Elise Rosson,

François Lux, Laurent David

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125555 - 125555

Published: April 1, 2025

Peptides are bioactive intermediates between small organic molecules and large biological compounds like antibodies or proteins. These play a unique valuable role as therapeutic agents, owing to their biochemical properties versatility in treating wide range of diseases such metabolic disorders, cancer therapy, antimicrobial anti-inflammatory agents. The global peptide therapeutics market is projected exceed USD 50 billion by 2024, reflecting the increasing demand interest this field. Therapeutic peptides offer an optimal balance specificity, safety, molecular size, providing greater precision targeting specific receptors with fewer off-target effects reduced toxicity compared small-organic drugs. also exhibit enhanced tissue penetration present simpler, cheaper manufacturing processes lower immunogenicity. To date, around 100 have attained clinical approval major markets, nearly half these approvals occurring past 20 years. This trend highlights growing importance potential modern medicine, explaining substantial associated treatments. review presents detailed comparison parenteral administration modes for peptides, specifically subcutaneous intravenous routes. We highlight how methods impact pharmacokinetic profiles influence patient outcomes, critical insights into advantages limitations each route. Finally, significant aspect its focus on innovative drug delivery systems formulations designed address challenges delivery, namely stability, bioavailability, efficacy.

Language: Английский

Focus on therapeutic peptides and their delivery DOI Creative Commons

Elise Rosson,

François Lux, Laurent David

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125555 - 125555

Published: April 1, 2025

Peptides are bioactive intermediates between small organic molecules and large biological compounds like antibodies or proteins. These play a unique valuable role as therapeutic agents, owing to their biochemical properties versatility in treating wide range of diseases such metabolic disorders, cancer therapy, antimicrobial anti-inflammatory agents. The global peptide therapeutics market is projected exceed USD 50 billion by 2024, reflecting the increasing demand interest this field. Therapeutic peptides offer an optimal balance specificity, safety, molecular size, providing greater precision targeting specific receptors with fewer off-target effects reduced toxicity compared small-organic drugs. also exhibit enhanced tissue penetration present simpler, cheaper manufacturing processes lower immunogenicity. To date, around 100 have attained clinical approval major markets, nearly half these approvals occurring past 20 years. This trend highlights growing importance potential modern medicine, explaining substantial associated treatments. review presents detailed comparison parenteral administration modes for peptides, specifically subcutaneous intravenous routes. We highlight how methods impact pharmacokinetic profiles influence patient outcomes, critical insights into advantages limitations each route. Finally, significant aspect its focus on innovative drug delivery systems formulations designed address challenges delivery, namely stability, bioavailability, efficacy.

Language: Английский

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