Poly (Lipoic Acid) Hydrogel Dressings With Adhesion, Self‐Healing, and Self‐Adaptive Properties via Dynamic Bonding

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Self‐healing hydrogels have become a hot research topic in the field of wound care due to their ability prevent secondary damage dressing and reduce risk infection. The aim this study was develop hydrogel network system with excellent self‐healing antimicrobial properties, which is particularly suitable for applications. stability enhanced by forming long chains through lipoic acid (LA) disulfide bonding inhibiting chain depolymerization via polygallic (PGA)‐mediated SAr bonding. In addition, poly(lysine) (PL) doped into electrostatic interactions further enhance structural strength properties hydrogels. This noncovalent gel endowed softness fluidity, enabling them adapt various shapes. Through experimental results, it shown that not only possessed mechanical remarkable ability, but also exhibited good cytocompatibility. Antimicrobial tests more than 99.9% effective against Escherichia coli Staphylococcus aureus . Thus, PLA/PGA/PL self‐healing, antimicrobial, biocompatibility shows great potential application as dressings becomes strong candidate dressings.

Language: Английский

Mechanisms of bone regeneration repair and potential and efficacy of small molecule drugs

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118070 - 118070

Published: April 21, 2025

Language: Английский