Supramolecular Peptide Depots for Glucose‐Responsive Glucagon Delivery DOI Open Access
Weike Chen,

Sihan Yu,

Bernice Webber

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 113(1)

Published: Dec. 25, 2024

ABSTRACT Precise blood glucose control continues to be a critical challenge in the treatment and management of type 1 diabetes order mitigate both acute chronic complications. This study investigates development supramolecular peptide amphiphile (PA) material functionalized with phenylboronic acid (PBA) for glucose‐responsive glucagon delivery. The PA‐PBA system self‐assembles into nanofibrillar hydrogels presence physiological levels, resulting stable capable releasing under hypoglycemic conditions. Glucose responsiveness is driven by reversible binding between PBA glucose, which modulates electrostatic interactions necessary hydrogel formation dissolution. Through comprehensive vitro characterization, including circular dichroism, zeta potential measurements, rheological assessments, found exhibit glucose‐dependent assembly, enabling controlled release that inversely related concentration. Glucagon accelerated low conditions, simulating state, reduced rate seen at higher levels. Evaluation platform vivo using diabetic mouse model demonstrates efficacy protecting against insulin‐induced hypoglycemia restoring levels following an insulin overdose. ability tailor response fluctuating concentrations underscores this improving glycemic control. These findings suggest glucose‐stabilized hold significant promise responsive drug delivery applications, offering approach manage other metabolic disorders.

Language: Английский

From Sea Cucumbers to Soft Robots: A Photothermal-Responsive Hydrogel Actuator with Shape Memory DOI

Jinxue Zhao,

Xuejing Zhai, Peiyi Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Soft robotics has undergone considerable progress driven by materials that can effectively transduce external stimuli into mechanical actuation. Here, we report the development of a photothermal-responsive hydrogel actuator with shape memory capabilities inspired adaptive locomotion sea cucumbers. This is based on cucumber peptides (SCP) and liquid metal (LM) network responsive to near-infrared (NIR) light. Upon NIR irradiation, undergoes phase transition from swollen collapsed state, resulting in controlled volumetric change. Incorporating polymer (SMP) matrix facilitates actuator's retention its deformed configuration following stimulus removal, thereby enabling intricate, multiphase transformations. SCP/LM overcomes limitations traditional hydrogels achieves good stretchability (3,000%) enough adhesion (21 kPa), exhibiting no toxicity human cells. Furthermore, exhibited significant bending complex deformation within 100 s exposure. offers new opportunities for soft biomedical applications, showcasing potential pathway incorporating next generation smart devices.

Language: Английский

Citations

0
Supramolecular Peptide Depots for Glucose‐Responsive Glucagon Delivery DOI Open Access
Weike Chen,

Sihan Yu,

Bernice Webber

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 113(1)

Published: Dec. 25, 2024

ABSTRACT Precise blood glucose control continues to be a critical challenge in the treatment and management of type 1 diabetes order mitigate both acute chronic complications. This study investigates development supramolecular peptide amphiphile (PA) material functionalized with phenylboronic acid (PBA) for glucose‐responsive glucagon delivery. The PA‐PBA system self‐assembles into nanofibrillar hydrogels presence physiological levels, resulting stable capable releasing under hypoglycemic conditions. Glucose responsiveness is driven by reversible binding between PBA glucose, which modulates electrostatic interactions necessary hydrogel formation dissolution. Through comprehensive vitro characterization, including circular dichroism, zeta potential measurements, rheological assessments, found exhibit glucose‐dependent assembly, enabling controlled release that inversely related concentration. Glucagon accelerated low conditions, simulating state, reduced rate seen at higher levels. Evaluation platform vivo using diabetic mouse model demonstrates efficacy protecting against insulin‐induced hypoglycemia restoring levels following an insulin overdose. ability tailor response fluctuating concentrations underscores this improving glycemic control. These findings suggest glucose‐stabilized hold significant promise responsive drug delivery applications, offering approach manage other metabolic disorders.

Language: Английский

Citations

0