A Re-evaluation of the Optimal Liver Copper Concentrations for Health, Performance and Fertility of Replacement Holstein–Friesian Heifers DOI Creative Commons
Amanda C. Marsh, L.A. Sinclair, Joe M. Roberts

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Excessive copper (Cu) supplementation is common on dairy farms worldwide, despite a growing body of research highlighting the risks over-supplementation, including liver damage, impaired growth, and reduced fertility. However, diagnosing Cu toxicity remains challenging due to liver's allostatic regulation blood levels debate surrounding thresholds. This study utilised secondary data from longitudinal conducted between September 2016 2018 involving 80 replacement Holstein-Friesian heifers. Data was generate receiver operating characteristic curves which established thresholds associated with suboptimal function Results indicated that hepatic concentrations exceeding 167 mg/kg dry matter (DM) were conception rates first service, while above 260 DM probability second services. Hepatic 322 linked function, as evidenced by elevated serum glutamate dehydrogenase activity. In contrast, threshold value could not be generated for plasma Cu, underscoring its inadequacy biomarker. The fertility identified in this may more closely related optimizing animal performance rather than indicative toxicity, suggesting need further research.

Language: Английский

Integrating cuproptosis and immunosenescence: A novel therapeutic strategy in cancer treatment DOI
Ali Ahmadizad Firouzjaei, Seyed Hamid Aghaee‐Bakhtiari

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 101983 - 101983

Published: March 29, 2025

Language: Английский

Citations

0
Multi-pathway copper metabolisms regulation based on an engineered copper/ferrous nanoplatform for enhanced tumor cuproptosis therapy DOI

Yun Gao,

Renlu Han, Zhen Guo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114682 - 114682

Published: April 1, 2025

Language: Английский

Citations

0
A Re-evaluation of the Optimal Liver Copper Concentrations for Health, Performance and Fertility of Replacement Holstein–Friesian Heifers DOI Creative Commons
Amanda C. Marsh, L.A. Sinclair, Joe M. Roberts

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Excessive copper (Cu) supplementation is common on dairy farms worldwide, despite a growing body of research highlighting the risks over-supplementation, including liver damage, impaired growth, and reduced fertility. However, diagnosing Cu toxicity remains challenging due to liver's allostatic regulation blood levels debate surrounding thresholds. This study utilised secondary data from longitudinal conducted between September 2016 2018 involving 80 replacement Holstein-Friesian heifers. Data was generate receiver operating characteristic curves which established thresholds associated with suboptimal function Results indicated that hepatic concentrations exceeding 167 mg/kg dry matter (DM) were conception rates first service, while above 260 DM probability second services. Hepatic 322 linked function, as evidenced by elevated serum glutamate dehydrogenase activity. In contrast, threshold value could not be generated for plasma Cu, underscoring its inadequacy biomarker. The fertility identified in this may more closely related optimizing animal performance rather than indicative toxicity, suggesting need further research.

Language: Английский

Citations

0