Capsaicin Mitigates Reverbα-Involved Lipid Metabolism Disorder in HepG2 Cells and Obese Mice through a Trpv1-Dependent Mechanism DOI
Ting Cao, Chi‐Tang Ho, Wenshuo Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Capsaicin (CAP), the active component of chili peppers, exerts a range health benefits, including anti-inflammatory, antitumor, obesity-prevention, metabolic control, and biological rhythm-modulating effects, primarily through activation transient receptor potential vanilloid 1 (TRPV1) receptor. The research explores role TRPV1 its interaction with hepatic circadian clock regulation in modulating lipid metabolism liver health. effect CAP on mechanism was examined HepG2 cells high-fat, high-sugar diet (HFFD)-induced obese mice. In vitro, (50 μM) decreased droplet overaccumulation (from 152.8 ± 2.30 to 110.13 3.91%), enhanced mitochondrial function 57.94 1.93 86.74 1.83%), alleviated desynchrony Trpv1-dependent cells. vivo, (5 mg/kg) reduced body weight gain 50.61 3.77 38.36 2.04%), restored rhythm, modulated expression lipid-related genes involvement This study highlighted attenuate Reverbα-mediated dysfunction mechanism, revealing complex interplay between metabolism.

Language: Английский

Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis DOI Creative Commons
Mari C. Vázquez‐Borrego, Mercedes del Río-Moreno, Maxim Pyatkov

et al.

Metabolism, Journal Year: 2023, Volume and Issue: 144, P. 155589 - 155589

Published: May 13, 2023

Language: Английский

Citations

13
Patchouli alcohol alleviates metabolic dysfunction-associated steatohepatitis via inhibiting mitochondria-associated endoplasmic reticulum membrane disruption-induced hepatic steatosis and inflammation in rats DOI

Xingyu Xie,

Ying-Yi Liao, Zixin Lin

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112634 - 112634

Published: July 6, 2024

Language: Английский

Citations

4
Regulation of bile acids and their receptor FXR in metabolic diseases DOI Creative Commons
Yao Li, Lulu Wang, Yi Qing

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 11, 2024

High sugar, high-fat diets and unhealthy lifestyles have led to an epidemic of obesity obesity-related metabolic diseases, seriously placing a huge burden on socio-economic development. A deeper understanding elucidation the specific molecular biological mechanisms underlying onset development has become key treatment diseases. Recent studies shown that changes bile acid composition are closely linked Bile acids can not only emulsify lipids in intestine promote lipid absorption, but also act as signaling molecules play indispensable role regulating homeostasis, energy expenditure, glucose metabolism, immunity. Disorders metabolism therefore important risk factors for The farnesol X receptor, member nuclear receptor family, is abundantly expressed liver intestinal tissues. endogenous ligands erroneous FXR triggered by dysregulation contributes including obesity, non-alcoholic fatty disease diabetes. Activation reduce lipogenesis inhibit gluconeogenesis alleviate It been found regulate hepatic organ-wide manner. crosstalk between provides new idea This review focuses relationship diseases current research progress provide theoretical basis further clinical applications.

Language: Английский

Citations

4
Ursolic acid attenuates obesity-related metabolic dysfunction via modulation of peroxisome proliferator activated receptor-gamma in male Wistar rats fed with high-carbohydrate high-fat diet DOI Creative Commons
O Omodara, M.U. Kawu, I. G. Bako

et al.

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 6, 2025

Abstract Background The risk factors of metabolic syndrome (MS) precedes the development cardiovascular disease and type 2 diabetes are largely triggered by high-carbohydrate high-fat diet (HCHFD) sedentary lifestyle. these is connected to persistent low-grade inflammation. Though, ursolic acid (UA) has been shown prevent HCHFD-induced parameters. present study aimed elucidate molecular mechanisms underlying preventive effects dietary UA supplementation on obesity-related disorders inflammation in male Wistar rats fed with HCHFD. animals were randomly divided into 4 groups (n = 5): 1—normal (ND) + distilled water (DW); 2—ND UA; 3—HCHFD DW; 4—HCHFD UA. HCHFD was augmented 20% fructose drinking water. their respective diets daily for 20 weeks. 250 mg/kg body weight administered orally UA-treated last 8 Blood samples collected liver adipose tissues harvested biochemical tissue analysis, respectively. Results BMI FBG significantly lowered UA-fed compared DW-fed animals. In animals, HOMA-IR, serum insulin, cholesterol, triglyceride low-density lipoprotein cholesterol (LDL-C) decreased while high-density (HDL-C) increased tumor necrosis factor alpha (TNF-α) interleukin-6 (IL-6) adiponectin level messenger ribonucleic (mRNA) peroxisome proliferator activated receptor-gamma (PPAR-γ) upregulated PPAR-γ mRNA downregulated DW group, restored architecture parenchyma near normal. Conclusion Dietary mitigated dysfunction associated obesity via modulation

Language: Английский

Citations

0
Capsaicin Mitigates Reverbα-Involved Lipid Metabolism Disorder in HepG2 Cells and Obese Mice through a Trpv1-Dependent Mechanism DOI
Ting Cao, Chi‐Tang Ho, Wenshuo Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Capsaicin (CAP), the active component of chili peppers, exerts a range health benefits, including anti-inflammatory, antitumor, obesity-prevention, metabolic control, and biological rhythm-modulating effects, primarily through activation transient receptor potential vanilloid 1 (TRPV1) receptor. The research explores role TRPV1 its interaction with hepatic circadian clock regulation in modulating lipid metabolism liver health. effect CAP on mechanism was examined HepG2 cells high-fat, high-sugar diet (HFFD)-induced obese mice. In vitro, (50 μM) decreased droplet overaccumulation (from 152.8 ± 2.30 to 110.13 3.91%), enhanced mitochondrial function 57.94 1.93 86.74 1.83%), alleviated desynchrony Trpv1-dependent cells. vivo, (5 mg/kg) reduced body weight gain 50.61 3.77 38.36 2.04%), restored rhythm, modulated expression lipid-related genes involvement This study highlighted attenuate Reverbα-mediated dysfunction mechanism, revealing complex interplay between metabolism.

Language: Английский

Citations

0