Cellular Signalling, Journal Year: 2012, Volume and Issue: 24(6), P. 1185 - 1194
Published: Feb. 4, 2012
Language: Английский
Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2013, Volume and Issue: unknown, P. 27 - 48
Published: Jan. 1, 2013
Language: Английский
Citations
403
Cell Death and Disease, Journal Year: 2014, Volume and Issue: 5(10), P. e1506 - e1506
Published: Oct. 30, 2014
Abstract Long noncoding RNAs (lncRNAs) have important roles in diverse biological processes. Our previous study has revealed that lncRNA-MALAT1 deregulation is implicated the pathogenesis of diabetes-related microvascular disease, diabetic retinopathy (DR). However, role MALAT1 retinal vasculature remodeling still remains elusive. Here we show expression significantly upregulated retinas STZ-induced rats and db/db mice. knockdown could obviously ameliorate DR vivo , as shown by pericyte loss, capillary degeneration, leakage, inflammation. Moreover, regulate endothelial cell proliferation, migration, tube formation vitro . The crosstalk between p38 MAPK signaling pathway involved regulation function. upregulation represents a critical pathogenic mechanism for diabetes-induced dysfunction. Inhibition may serve potential target anti-angiogenic therapy complications.
Language: Английский
Citations
402
New England Journal of Medicine, Journal Year: 2018, Volume and Issue: 378(3), P. 250 - 261
Published: Jan. 17, 2018
Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in brain vasculature, a leading cause hemorrhagic stroke young adults children. The genetic this rare focal disorder is unknown.
Language: Английский
Citations
398
Ageing Research Reviews, Journal Year: 2016, Volume and Issue: 29, P. 90 - 112
Published: June 26, 2016
Language: Английский
Citations
397
Cellular Signalling, Journal Year: 2012, Volume and Issue: 24(6), P. 1185 - 1194
Published: Feb. 4, 2012
Language: Английский
Citations
383