Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis

Biological and Pharmaceutical Bulletin, Journal Year: 2015, Volume and Issue: 39(1), P. 1 - 24

Published: Dec. 31, 2015

Increased levels of apolipoprotein B (apoB)-containing lipoproteins, such as low density lipoproteins (LDL) and chylomicron remnants, are associated with the development atherosclerosis. Chylomicrons containing apoB-48 secreted from intestine during postprandial state, whereas very (VLDL) apoB-100 constitutively formed in liver. Chylomicron remnants VLDL produced by lipoprotein lipase-mediated lipolysis triglycerides, which is activated C-II bound on particle surfaces. The hepatic uptake these facilitated E (apoE), but inhibited apolipoproteins C-I, C-III. In plasma, further converted into LDL hydrolysis triglycerides. ApoB-100 responsible for LDL. receptor, receptor-related protein heparan sulfate proteoglycans involved clearance and/or apoE. subendothelial retention modification apoB-containing crucial events initiation subendothelium, modified macrophages leads to formation foam cells storing excess amounts cholesteryl esters subsequently apoptosis. This review describes current knowledge about metabolism dyslipidemia atherogenesis. particular, I focus effects apolipoproteins, lipid composition size roles cholesterol, sphingomyelinase apoB denaturation macrophage cell A detailed understanding mechanisms will help develop new therapeutic strategies.

Language: Английский

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Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: The Very Large Database of Lipids-4 (VLDL-4) study

Atherosclerosis, Journal Year: 2015, Volume and Issue: 242(1), P. 243 - 250

Published: July 7, 2015

Language: Английский

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Postprandial lipoproteins and the molecular regulation of vascular homeostasis

Progress in Lipid Research, Journal Year: 2013, Volume and Issue: 52(4), P. 446 - 464

Published: June 15, 2013

Language: Английский

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Elevated high-density lipoprotein cholesterol and cardiovascular mortality in maintenance hemodialysis patients

Nephrology Dialysis Transplantation, Journal Year: 2014, Volume and Issue: 29(8), P. 1554 - 1562

Published: Feb. 25, 2014

High-density lipoprotein (HDL) confers protection against atherosclerosis by several different mechanisms. Although in the general population, increasing levels of HDL are associated with reduced cardiovascular (CV) mortality, this association is not well known patients chronic disease states such as end-stage renal disease. We hypothesize that serum concentration and its ratio to total cholesterol all-cause CV mortality hemodialysis from population. A 3-year (July 2004 June 2007) cohort 33 109 was studied USA dialysis clinics where lipid profile measured at least 50% all outpatients clinic during a given calendar quarter. Cox proportional hazard models were adjusted for demographics case–mix variables cubic splines plotted. Higher concentrations up 50 mg/dL better overall survival, while 60 above rise mortality. All-cause 1.28 (1.20–1.38) 1.08 (1.01–1.16) <30 1.05 (1.00–1.10) (1.00–1.16) ≥ mg/dL, respectively (reference: HDL: 30–<60 mg/dL). In contrast low higher patients. U-shaped between level exists <60 exhibiting best survival. The underlying mechanisms responsible these seemingly paradoxical associations await further investigation.

Language: Английский

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Hyperlipidemia and risk for preclampsia

Journal of clinical lipidology, Journal Year: 2022, Volume and Issue: 16(3), P. 253 - 260

Published: Feb. 20, 2022

Language: Английский

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In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide

Kidney International, Journal Year: 2009, Volume and Issue: 76(4), P. 437 - 444

Published: May 27, 2009

Language: Английский

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Lipotoxicity and Impaired High Density Lipoprotein-Mediated Reverse Cholesterol Transport in Chronic Kidney Disease

Journal of Renal Nutrition, Journal Year: 2010, Volume and Issue: 20(5), P. S35 - S43

Published: Aug. 25, 2010

Language: Английский

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Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases

International Journal of Vascular Medicine, Journal Year: 2011, Volume and Issue: 2012, P. 1 - 11

Published: Sept. 25, 2011

Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the syndrome and, diabetes. Remnant become attached to wall, where they can penetrate intact endothelium causing foam cell formation. activate circulating leukocytes, upregulate expression endothelial adhesion molecules, facilitate migration inflammatory cells into subendothelial space, complement system. Since humans are postprandial most day, continuous generation remnants after each meal may be one triggers for development atherosclerosis. Modulation lipemia by lifestyle changes pharmacological interventions could result in further decrease cardiovascular mortality morbidity. This paper will provide an update on current concepts concerning relationship between lipemia, inflammation, function, therapeutic options.

Language: Английский

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Modified Low Density Lipoprotein and Lipoprotein-Containing Circulating Immune Complexes as Diagnostic and Prognostic Biomarkers of Atherosclerosis and Type 1 Diabetes Macrovascular Disease

International Journal of Molecular Sciences, Journal Year: 2014, Volume and Issue: 15(7), P. 12807 - 12841

Published: July 21, 2014

In atherosclerosis; blood low-density lipoproteins (LDL) are subjected to multiple enzymatic and non-enzymatic modifications that increase their atherogenicity induce immunogenicity. Modified LDL capable of inducing vascular inflammation through activation innate immunity; thus, contributing the progression atherogenesis. The immunogenicity modified results in induction self-antibodies specific a certain type LDL. antibodies react with forming circulating immune complexes. Circulating complexes exhibit prominent immunomodulatory properties influence atherosclerotic inflammation. Compared freely LDL; associated have more robust atherogenic proinflammatory potential. Various lipid components may serve not only as diagnostic but also essential predictive markers cardiovascular events atherosclerosis. Accumulating evidence indicates LDL-containing can biomarker for macrovascular disease 1 diabetes.

Language: Английский

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Glucolipotoxicity: A Proposed Etiology for Wooden Breast and Related Myopathies in Commercial Broiler Chickens

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: March 13, 2020

Wooden breast is one of several myopathies fast-growing commercial broilers that has emerged as a consequence intensive selection practices in the poultry breeding industry. Despite substantial economic burden presented to broiler producers worldwide by wooden and related muscle disorders such white striping, genetic etiological underpinnings these diseases are still poorly understood. Here we propose new hypothesis on primary causes implicates dysregulation lipid glucose metabolism. Our addresses recent findings have suggested etiologic similarities between type 2 diabetes despite their phenotypic disparities. Unlike mammals, metabolism not accompanied an increase plasma levels but generates unique skeletal phenotype, i.e., breast, chickens. We hypothesize disparities result from major difference transport birds phenotype most closely resembles complications smooth cardiac mammals. Additional basic research chickens necessary can be informative for production well human health disease. To inform future studies, this paper reviews current biological knowledge outlines steps its proposed pathogenesis, examines how traits may contributed prevalence.

Language: Английский

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