Translational photobiology: towards dynamic lighting in indoor horticulture DOI Creative Commons
Ulrike Bechtold, Meike Burow, Saijaliisa Kangasjärvi

et al.

Trends in Plant Science, Journal Year: 2024, Volume and Issue: 30(3), P. 301 - 310

Published: Oct. 31, 2024

Language: Английский

A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis DOI Creative Commons
Xiaotong Jiang, Amanda M. Koenig, Berkley J. Walker

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 30, 2025

Language: Английский

Citations

0
Artesunate induces ferroptosis in osteosarcoma through NCOA4‐mediated ferritinophagy DOI Creative Commons
Rui Huang, Ruiqing Xu, Jiandang Shi

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)

Published: April 1, 2025

Abstract Osteosarcoma (OS) is a prevalent primary malignant bone tumor that lacks effective therapeutic interventions. Artesunate (ART) has been proved to have remarkable treatment effects on severe malaria and anti‐tumor properties. This study aimed investigate the anti‐OS underlying mechanisms of ART. The potential ART‐mediated activity were analyzed by using RNA sequencing, iron accumulation, lipid peroxidation, western blotting, small interfering (siRNA) transfection. In vivo, xenograft mice model was adopted explore anticancer effect present revealed ART significantly suppressed OS cell proliferation. Subsequent results suggested exerted mainly through ferroptosis pathway. decreased GSH/GSSG ratio, xCT GPX4 expression, while increasing MDA which reversed Fer‐1, DFO, 3‐MA, NCOA4 silencing. Mechanistically, upregulated expression TFR DMT1, triggered ferritinophagy upregulating NCOA4, increased Fe 2+ accumulation ferroptosis. addition, cytoplasmic further activated Mfrn2‐mediated transportation free into mitochondria, resulting in mitochondrial overload, eventually leading peroxidation Furthermore, an mouse model, administration inhibited growth Collectively, our findings indicated capacity NCOA4‐mediated ferritinophagy, might shed light future therapy.

Language: Английский

Citations

0
Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis DOI Creative Commons
Rui Huang,

Dawei Chu,

Jiandang Shi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Osteosarcoma (OS) is a prevalent primary malignant bone tumor which lacks effective therapeutic interventions. Ferroptosis new form of programmed cell death characterized by iron-dependent accumulation lethal lipid oxidation, provides potential alternative intervene for the OS treatment. Shikonin major bioactive component extracted from roots lithospermum erythrorhizon also known as "Zicao" in traditional Chinese medicine, has been proved to have exhibits remarkable anti-tumor properties several cancers. However, whether ferroptosis participated shikonin mediated anti-OS activity still remains be clarified. Herein, we provide evidence that possesses capability induce ferroptosis, and elucidate underlying mechanisms treatment OS. In present study, it was found significantly suppressed cells proliferation blocked cycle progression

Language: Английский

Citations

1
Translational photobiology: towards dynamic lighting in indoor horticulture DOI Creative Commons
Ulrike Bechtold, Meike Burow, Saijaliisa Kangasjärvi

et al.

Trends in Plant Science, Journal Year: 2024, Volume and Issue: 30(3), P. 301 - 310

Published: Oct. 31, 2024

Language: Английский

Citations

0