Future atherosclerotic cardiovascular disease in systemic lupus erythematosus based on CSTAR (XXVIII): the effect of different antiphospholipid antibodies isotypes

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 6, 2025

Patients with systemic lupus erythematosus (SLE) suffered from an increasing risk of cardiovascular diseases. In this multi-center prospective study, we aimed to determine the association between antiphospholipid antibodies (aPLs) and future atherosclerotic disease (ASCVD) in SLE. total, 1573 SLE patients were recruited based on Chinese Treatment Research group (CSTAR) registry. aPLs profile, including anticardiolipin (aCL) IgG/IgM, anti-β2 glycoprotein I (aβ2GPI) anticoagulant (LA), measured each center. Future ASCVD events defined as new-onset myocardial infarction, stroke, artery revascularization, or death. Among patients, 525 (33.4%) had positive aPLs. LA highest prevalence (324 [20.6%]), followed by aCL IgG (249 [15.8%]), aβ2GPI (199 [12.7%]). 116 (7.37%) developed during mean follow-up 4.51 ± 2.32 years 92 positive. univariate Cox regression analysis, both (HR = 7.81, 95% CI 5.00–12.24, p < 0.001) traditional factors associated events. multiple 1.95, 1.25–3.00, 0.003), IgM 1.83, 1.03–3.20, 0.039), 5.13, 3.23–8.20, positivity remained ASCVD; for ASCVD, smoking, gender, age hypertension, also play independent role patients. More importantly, Aspirin can reduce 0.57 CI, 0.25–0.93, P 0.026). aPLs, especially IgG/IgM LA, warrant more care surveillance follow-up. may have a protective effect ASCVD.

Language: Английский

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Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(6), P. 2092 - 2110

Published: Jan. 1, 2024

Development of non-surgical treatment human abdominal aortic aneurysm (AAA) has clinical significance. Colchicine emerges as an effective therapeutic regimen in cardiovascular diseases. Yet, whether colchicine slows AAA growth remain controversy. Here, we demonstrated that daily intragastric administration low-dose blocked formation, prevented vascular smooth muscle cell (SMC) phenotype switching and apoptosis, inflammation both peri-aortic CaPO

Language: Английский

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Small AAAs: Recommendations for Rodent Model Research for the Identification of Novel Therapeutics

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2024, Volume and Issue: 44(7), P. 1467 - 1473

Published: June 26, 2024

Most abdominal aortic aneurysms (AAAs) are small with low rupture risk (<1%/y) when diagnosed but slowly expand to ≥55 mm and undergo surgical repair. Patients clinicians require medications limit AAA growth rupture, drugs effective in animal models have not translated patients.

Language: Английский

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Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116800 - 116800

Published: Feb. 1, 2025

Language: Английский

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Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

BACKGROUND: Aortic dissection (AD) is a severe cardiovascular disorder characterized by intimal tearing and subsequent delamination of the aortic wall. The pathogenesis AD primarily involves phenotypic switch vascular smooth muscle cells (VSMCs), degradation extracellular matrix, chronic inflammation. Colchicine, an alkaloid derived from Colchicum autumnale L , Food Drug Administration–approved anti-inflammatory drug with established therapeutic applications in diseases. However, its potential role modulating development or progression remains largely unexplored. METHODS: To investigate effects colchicine on AD, β-aminopropionitrile–induced mouse model was used. Colchicine administered via oral gavage over 3-week period to evaluate impact incidence mortality male C57BL/6J mice. Transcriptome sequencing performed identify genes signaling pathways regulated colchicine. Additionally, vitro experiments using primary rat VSMCs were conducted elucidate mechanisms underlying colchicine-mediated regulation VSMC switch. RESULTS: demonstrated protective effect against attenuating inflammation suppressing Mechanistically, reverses at least partially expression myocardin, key regulator contractile phenotype. Transcriptomic analysis further revealed specific influenced colchicine, providing insights into molecular action. CONCLUSIONS: This study identifies as for highlighting ability mitigate hallmark pathological processes such These findings offer foundation base repurposed clinical application which warrants investigation.

Language: Английский

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Potential application of peripheral blood biomarkers in intracranial aneurysms

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 19, 2023

Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis treatment rely on costly equipment, lacking effective indicators for progression prediction specific drugs treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune inflammatory state of body in real-time, have shown promise providing additional information risk stratification IA patients, which may improve their outcomes rupture through anti-inflammatory therapy. Therefore, this paper reviewed progress potential biomarkers IAs, including indicators, cytokines, lipids, aiming to aid individual management therapy aneurysms practices.

Language: Английский

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Colchicine ameliorates short-term abdominal aortic aneurysms by inhibiting the expression of NLRP3 inflammasome components in mice

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 964, P. 176297 - 176297

Published: Dec. 20, 2023

Abdominal aortic aneurysms (AAA) are often associated with chronic inflammation and pose a significant risk to affected individuals. Colchicine, known for its anti-inflammatory properties, has shown promise in managing cardiovascular diseases. However, specific role the development of AAA remains poorly understood.

Language: Английский

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Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

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