A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders DOI Creative Commons
Wenming Wei, Xin Qi, Bolun Cheng

et al.

Communications Medicine, Journal Year: 2024, Volume and Issue: 4(1)

Published: Dec. 18, 2024

Musculoskeletal disorders pose major public health challenges, and accelerated biological aging may increase their risk. This study investigates the association between musculoskeletal disorders, with a focus on sex-related differences. We analyzed data from 172,332 UK Biobank participants (mean age of 56.03 ± 8.10 years). Biological was calculated using KDM-BA PhenoAge algorithms based blood biomarkers. were diagnosed ICD-10 criteria, sample sizes ranging 1,182 to 23,668. Logistic regression assessed cross-sectional associations acceleration (AA) metrics disorders. Accelerated Failure Time (AFT) model used for survival analysis evaluate relationships AAs onset. Models adjusted demographic, lifestyle, socio-economic covariates. The threshold P-values set by Holm-Bonferroni correction. Cross-sectional analyses reveal significant fourteen Survival indicate that significantly accelerate onset nine including inflammatory polyarthropathies (RTKDM-BA = 0.993; RTPhenoAge 0.983), systemic connective tissue 0.987; 0.980), spondylopathies (RTPhenoAge= 0.994), bone density structure 0.991), gout 0.968), arthritis pain in joint 0.989), low back 0.986), osteoporosis 0.994). Sensitivity are consistent primary findings. Sex-specific variations observed, accelerating spondylopathies, arthritis, females, while is males. associated incidence several These insights highlight importance assessments gauging disorder risk, aiding early detection, prevention, management. As we age, our bodies experience changes can lead problems, such as pain. explores how aging, measure old seem biomarkers, affects risk developing these Using over 170,000 people, found faster linked an increased risks vary men women. findings could help identify people at earlier, leading better prevention treatment strategies. Wei et al. investigate link highlighting disparities. Age increases notable differences males females.

Language: Английский

Episodic denervation as a driver of loss of skeletal muscle redox homeostasis and muscle weakness in sarcopenia: Possible amelioration by exercise DOI Creative Commons
Malcolm J. Jackson

Sports Medicine and Health Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Age-Related Changes in Insulin Resistance and Muscle Mass: Clinical Implications in Obese Older Adults DOI Creative Commons
Ali A. Rizvi, Manfredi Rizzo

Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1648 - 1648

Published: Oct. 8, 2024

The older segment of the global population is increasing at a rapid pace. Advancements in public health and modern medicine lengthened life expectancy reduced burden disease communities worldwide. Concurrent with this demographic change rise overweight people obesity, which evident all age groups. There also an aging-related reduction muscle mass function, or sarcopenia, that exacerbated by sedentary lifestyle poor nutrition. coexistence loss elevated body index, termed “sarcopenic obesity”, has particularly deleterious consequences individuals. Worsening insulin resistance proinflammatory state operate pathophysiologic level lead to adverse outcomes such as proclivity cardiovascular disease, type 2 diabetes, even cognitive dysfunction. Although concept sarcopenic obesity construct being increasingly recognized, clearer understanding warranted order define its components impact. Research needed molecular-cellular tie together derangements action, cytokines, myokines, endothelial dysfunction clinical outcomes. Lifestyle modifications well targeted nonpharmacologic approaches, supplements antioxidants, appear have promising role reducing chronic emerging disorder. Breakthroughs drug therapies retard reverse underlying dynamics sarcopenia persons are actively explored.

Language: Английский

Citations

3
Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies DOI
Yajing Gao, Yuli Huang, Ran An

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 133, P. 105807 - 105807

Published: March 1, 2025

Language: Английский

Citations

0
Intra-Session Reliability and Predictive Value of Maximum Voluntary Isometric Contraction for Estimating One-Repetition Maximum in Older Women: A Randomised Split-Sample Study DOI Creative Commons
José Aldo Hernández-Murúa, Ena Monserrat Romero-Pérez,

Jorge Luis Guajardo-Cruztitla

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(2), P. 160 - 160

Published: May 6, 2025

Background: Ageing is associated with a progressive decline in muscle strength, particularly the lower limbs, which compromises functional independence. While both maximum voluntary isometric contraction (MVIC) and one-repetition (1RM) are widely employed to assess intra-session reliability predictive capacity of MVIC for estimating 1RM older women remain insufficiently explored. Objectives: This study aims evaluate knee extensors, analyse its correlation 1RM, develop model from women. Methods: Using randomised split-sample design, 82 aged 60–69 years performed two trials one test using leg extension machine. Intra-session was assessed by calculating intraclass coefficient (ICC), standard error measurement (SEM), minimal detectable change (MDC). Furthermore, linear regression developed predict based on MVIC. Results: demonstrated excellent (ICC = 0.96, SEM 4.3%, MDC 11.9%), strong between observed (R2 0.618). Although equation [(0.932 × MVIC) − 3.852] did not yield statistically significant differences estimated actual values (p 0.791), it exhibited prediction 13.4%. Conclusions: highly reliable measure represents practical tool 1RM. Nonetheless, accuracy limited, highlighting need further studies refine models incorporating additional variables.

Language: Английский

Citations

0
Impact of Exercise on Physiological, Biochemical, and Analytical Parameters in Patients with Heart Failure with Reduced Ejection Fraction DOI Creative Commons
Francisco Epelde

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 2017 - 2017

Published: Dec. 6, 2024

Heart failure with reduced ejection fraction (HFrEF) is a condition marked by diminished cardiac output and impaired oxygen delivery to tissues. Exercise, once avoided in HFrEF patients due safety concerns, now recognized as an important therapeutic intervention. Structured exercise improves various physiological, biochemical, analytical parameters, including output, endothelial function, skeletal muscle performance, autonomic regulation. Biochemically, induces favorable changes inflammatory markers, lipid profiles, glucose metabolism, renal function. This paper reviews these changes, highlighting how can be safely incorporated into management. Further research needed tailor interventions for individual optimize outcomes.

Language: Английский

Citations

2
A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders DOI Creative Commons
Wenming Wei, Xin Qi, Bolun Cheng

et al.

Communications Medicine, Journal Year: 2024, Volume and Issue: 4(1)

Published: Dec. 18, 2024

Musculoskeletal disorders pose major public health challenges, and accelerated biological aging may increase their risk. This study investigates the association between musculoskeletal disorders, with a focus on sex-related differences. We analyzed data from 172,332 UK Biobank participants (mean age of 56.03 ± 8.10 years). Biological was calculated using KDM-BA PhenoAge algorithms based blood biomarkers. were diagnosed ICD-10 criteria, sample sizes ranging 1,182 to 23,668. Logistic regression assessed cross-sectional associations acceleration (AA) metrics disorders. Accelerated Failure Time (AFT) model used for survival analysis evaluate relationships AAs onset. Models adjusted demographic, lifestyle, socio-economic covariates. The threshold P-values set by Holm-Bonferroni correction. Cross-sectional analyses reveal significant fourteen Survival indicate that significantly accelerate onset nine including inflammatory polyarthropathies (RTKDM-BA = 0.993; RTPhenoAge 0.983), systemic connective tissue 0.987; 0.980), spondylopathies (RTPhenoAge= 0.994), bone density structure 0.991), gout 0.968), arthritis pain in joint 0.989), low back 0.986), osteoporosis 0.994). Sensitivity are consistent primary findings. Sex-specific variations observed, accelerating spondylopathies, arthritis, females, while is males. associated incidence several These insights highlight importance assessments gauging disorder risk, aiding early detection, prevention, management. As we age, our bodies experience changes can lead problems, such as pain. explores how aging, measure old seem biomarkers, affects risk developing these Using over 170,000 people, found faster linked an increased risks vary men women. findings could help identify people at earlier, leading better prevention treatment strategies. Wei et al. investigate link highlighting disparities. Age increases notable differences males females.

Language: Английский

Citations

0