Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline DOI Creative Commons
Leon F. Willis, Nikil Kapur, Sheena E. Radford

et al.

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 413 - 432

Published: Dec. 1, 2024

The successful progression of therapeutic antibodies and other biologics from the laboratory to clinic depends on their possession "drug-like" biophysical properties. techniques resultant biochemical parameters used characterize ease manufacture can be broadly defined as developability. Focusing antibodies, this review firstly discusses established emerging probe early-stage developability biologics, aimed towards those new field. Secondly, we describe inter-relationships redundancies amongst assays how in silico methods aid efficient deployment bring a generation cost-effective proteins bench bedside more quickly sustainably.

Language: Английский

Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline DOI Creative Commons
Leon F. Willis, Nikil Kapur, Sheena E. Radford

et al.

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 413 - 432

Published: Dec. 1, 2024

The successful progression of therapeutic antibodies and other biologics from the laboratory to clinic depends on their possession "drug-like" biophysical properties. techniques resultant biochemical parameters used characterize ease manufacture can be broadly defined as developability. Focusing antibodies, this review firstly discusses established emerging probe early-stage developability biologics, aimed towards those new field. Secondly, we describe inter-relationships redundancies amongst assays how in silico methods aid efficient deployment bring a generation cost-effective proteins bench bedside more quickly sustainably.

Language: Английский

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