Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study
Archives of Dermatological Research,
Journal Year:
2025,
Volume and Issue:
317(1)
Published: Feb. 6, 2025
Abstract
The
rare
dermatological
condition
X-linked
ichthyosis
(XLI)
is
associated
with
a
substantially-increased
risk
of
cardiac
arrhythmias.
Arrhythmias
predispose
to
multiple
serious
health
conditions,
and
there
need
identify
them
at
an
early
stage,
ideally
using
non-invasive,
convenient,
cost-effective,
reliable
wearable
technology
methods.
We
tested
the
feasibility
monitoring
heart
rhythms
Apple
Watch
in
five
adult
males
from
United
Kingdom
diagnosed
XLI.
Participants
returned
routine
electrocardiogram
(ECG)
traces
watch
three
times
per
week
for
eight
weeks
(plus
any
‘watch
alerts’
indicating
arrhythmic
episodes)
cardiologist
review.
Participant
feedback
was
also
obtained
on
perceived
usability/wearability
watch/app,
study
requirements.
were
generally
happy
conduct,
found
watch/app
straightforward
use,
>
95%
data
return
rate.
Minor
protocol
improvements
suggested.
There
few
issues
reported
wearability
watch.
Three
participants
exhibited
no
ECG
abnormalities,
but
two
presented
ventricular
ectopic
beats
(VEs).
Only
one
‘alert’
returned,
this
considered
normal
sinus
rhythm,
suggesting
possibility
‘false
positive’
calls.
Based
our
small
sample,
smartwatch-based
screening
rhythm
abnormalities
high-risk
male
XLI
population
appears
useful,
feasible,
acceptable
patients
larger-scale
clinical
trial
warranted.
Potentially,
such
devices
may
be
more
suited
detecting
persistent
rather
than
unpredictable,
acute,
episodes.
high
VE
burden
some
consistent
septal
defects
underlying
arrhythmia
risk.
Language: Английский
Sulfation pathways in times of change
Essays in Biochemistry,
Journal Year:
2024,
Volume and Issue:
68(4), P. 379 - 382
Published: Dec. 1, 2024
Abstract
Sulfation
pathways
are
an
essential
part
of
overall
sulfur
metabolism.
mainly
about
sulfate
activation,
and
the
making
breaking
biological
esters.
This
special
issue
features
some
extended
reflection
on
what
was
presented
at
SUPA
2023
meeting
Pathways.
Novel
insights
into
synthesis
analytics
sulfate,
sulfated
conjugates,
protein
persulfides
presented.
Oxysterol
sulfates
as
emerging
sulfo-metabolites.
enzymes
discussed
in
various
disease
settings.
also
presents
polysaccharide
sulfotransferases
their
functional
characterization.
Finally,
cytoplasmic
highlighted
with
regards
to
impact
DNA-modification,
context
endocrine
disruptors.
All
all,
thought-provoking
findings,
potential
guide
stimulate
future
research
field
sulfation
beyond.
Language: Английский