Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 357 - 365
Published: Jan. 1, 2023
Language: Английский
Archives of Plastic Surgery, Journal Year: 2021, Volume and Issue: 48(06), P. 703 - 713
Published: Nov. 1, 2021
The field of vascularized composite allografts (VCAs) has undergone significant advancement in recent decades, and VCAs are increasingly common accepted the clinical setting, bringing hope functional recovery to patients with debilitating injuries. A major obstacle facing widespread application is side effect profile associated current immunosuppressive regimen, which can cause a wide array complications such as infection, malignancy, even death. Significant concerns remain regarding whether treatment outweighs risk. potential solution this dilemma would be achieving VCA tolerance, allow recipients receive without immunosuppression its sequelae. Promising tolerance protocols being studied kidney transplantation; four trials have attempted withdraw various successes. theme all use radiation donor cell transplantation. knowledge gained from these provide valuable insight into development protocol. Despite similarities, present additional barriers compared induction. donors likely deceased, limits time for pre-conditioning. also more human leukocyte antigen–mismatched, means that must induced across immunological barriers. This review explores adjunct therapies large animal models could missing element establishing safe stable induction method.
Language: Английский
Citations
15
Transplantation, Journal Year: 2024, Volume and Issue: 109(1), P. 142 - 152
Published: May 21, 2024
Long-term systemic immunosuppression is needed for vascularized composite allotransplantation (VCA). The high rate of acute rejection episodes in the first posttransplant year, development chronic rejection, and adverse effects that come along with this treatment, currently prevent a wider clinical application VCA. Opportunistic infections metabolic disturbances are among most observed side VCA recipients. To overcome these challenges, local using biomaterial-based drug delivery systems (DDS) have been developed. aim to provide concentrations immunosuppressive drugs while reducing their load. This review provides summary recently investigated DDS different mechanisms action such as on-demand, ultrasound-sensitive, or continuous delivery. In preclinical models, ranging from rodent porcine nonhuman primate approach has shown reduce tacrolimus (TAC) load effects, prolonging graft survival. Localized represents an encouraging enhance survival toxic patients. Preclinical models TAC-releasing demonstrated low burden. However, events translational animal reality, use additional low-dose TAC treatment may be envisaged. Patients benefit through efficient negligible resulting better compliance quality life.
Language: Английский
Citations
1
IntechOpen eBooks, Journal Year: 2022, Volume and Issue: unknown
Published: Jan. 26, 2022
The field of brachial plexus surgery has undergone dramatic changes in the past 40 years. Most these have been incremental nature. We seen increased use nerve grafts and transfers. introduction robotic limb replacements for most severe flail limbs where surgical intervention failed. In some cases, we an increase computer simulation virtual reality to train surgeons plan execute surgeries. More recently, technologies derived from regenerative medicine research.
Language: Английский
Citations
2
Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 357 - 365
Published: Jan. 1, 2023
Language: Английский
Citations
0