Post-traumatic stress disorder: molecular mechanisms of the intergenerational and transgenerational inheritance DOI
Е. Л. Паткин, И. О. Сучкова, Sergey G. Tsikunov

et al.

Успехи физиологических наук, Journal Year: 2024, Volume and Issue: 55(4), P. 3 - 26

Published: Dec. 8, 2024

Post-traumatic stress disorder is a mental that closely associated with dysfunction of the hypothalamic-pituitary-adrenal axis, and for its development required experience traumatic event causes negative emotions memories persist quite long time. The likelihood post-traumatic influenced both environmental factors, genetic epigenetic characteristics body. In this case modifications act as dynamic biomarkers (“nanotags”) impact environment on genome (epigenome), which can, under certain conditions, disappear or remain not only in an individual directly exposed to psychogenic trauma, but also transmitted over number generations. Review focuses possible mechanisms intergenerational transgenerational inheritance biological effects stress-related disorders.

Language: Английский

Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders DOI Open Access
Maria de Fátima dos Santos Sampaio,

Yara Bezerra de Paiva,

Tuane Bazanella Sampaio

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2024, Volume and Issue: 134(5), P. 574 - 601

Published: March 13, 2024

Abstract Studies have demonstrated the neuroprotective effect of cannabidiol (CBD) and other Cannabis sativa L. derivatives on diseases central nervous system caused by their direct or indirect interaction with endocannabinoid system‐related receptors molecular targets, such as 5‐HT 1A receptor, which is a potential pharmacological target CBD. Interestingly, CBD binding receptor may be suitable for treatment epilepsies, parkinsonian syndromes amyotrophic lateral sclerosis, in serotonergic plays key role. The aim this review was to provide an overview cannabinoid effects neurological disorders, epilepsy, multiple sclerosis Parkinson's diseases, discuss possible mechanism action, highlighting interactions targets phytocannabinoids. has been shown significant therapeutic epilepsy disease, while nabiximols contribute reduction spasticity are frequent option sclerosis. Although there theories cannabinoids substantially greater progress search strong scientific evidence effectiveness needed.

Language: Английский

Citations

12
MicroRNAs: A Novel Approach for Monitoring Treatment Response in Major Depressive Disorder? DOI Creative Commons
Cristina-Sorina Cătană, Monica Mihaela Marta, Daniel Ungureanu

et al.

Non-Coding RNA, Journal Year: 2025, Volume and Issue: 11(2), P. 21 - 21

Published: March 3, 2025

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders, with an increasing incidence each year and important socioeconomic burden. Although new treatments are continuously being developed, there no effective monitoring method to determine suitability treatment ensure positive outcomes. Therefore, patients often struggle ineffective antidepressants their potential adverse effects, which halts any future progress in managing disorder. Considering microRNAs (miRNAs) as biomarkers for various pathologies evidence modulation several genes involved MDD, this minireview aimed evaluate literature data on impact miRNAs MDD usefulness response. The correlations between expression support existence a common epigenetic mechanism explain differences influencing efficacy MDD.

Language: Английский

Citations

0
Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication DOI Creative Commons

Jingyu Xu,

B Wang,

Haiqing Ao

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that regulates secretion along the hypothalamic-pituitary-adrenal (HPA) axis, mediates neurotransmission humoral regulation. Due widespread expression of receptors (GR), effects CORT are almost ubiquitous in various tissue cells. Therefore, on one hand, is molecular signal activates body’s system during other due chemical properties GCs, anti-inflammatory act as stabilizers control response stress. Inflammation manifestation activation. plays dual roles this process both promoting inflammation exerting As hormone, levels fluctuate with degree duration stress, determining its changes it induces. essential for resist diseases maintain homeostasis, imbalance being key factor development diseases. understanding role mechanisms action immunity crucial. This review addresses important issue summarizes interactions between system.

Language: Английский

Citations

0
The differential effects of medicinal cannabis on mental health: A systematic review DOI
Nora de Bode, Emese Kroon, Sharon R. Sznitman

et al.

Clinical Psychology Review, Journal Year: 2025, Volume and Issue: unknown, P. 102581 - 102581

Published: March 1, 2025

Language: Английский

Citations

0
Identification of stress-induced epigenetic methylation onto dopamine D2 gene and neurological and behavioral consequences DOI Creative Commons
Kenneth Blum, Abdalla Bowirrat, David Baron

et al.

Gene & Protein in Disease, Journal Year: 2024, Volume and Issue: 3(1), P. 1966 - 1966

Published: March 29, 2024

The D2 dopamine receptor (DRD2) gene has garnered substantial attention as one of the most extensively studied genes across various neuropsychiatric disorders. Since its initial association with severe alcoholism in 1990, particularly through identification DRD2 Taq A1 allele, numerous international investigations have been conducted to elucidate role different conditions. As February 22, 2024, there are 5485 articles focusing on listed PUBMED. There 120 meta-analyses mixed results. In our opinion, primary cause negative reports regarding polymorphisms is inadequate screening controls, not adequately eliminating many hidden reward deficiency syndrome behaviors. Moreover, pleiotropic effects variants identified neuropsychologic, neurophysiologic, stress response, social defeat, maternal deprivation, and gambling disorder, epigenetic DNA methylation histone post-translational discussed this article. 70 PUBMED for 20 October 19, 2022. For commentary, we did denote and/or methylation; instead, provided a brief summary based behavioral effects. Based fact that Blum Noble characterized allele generalized necessarily specific alcoholism, it now behooves field find ways either use effector moieties edit neuroepigenetic insults or possibly harness idea potentially removing mRNA-reduced expression by inducing “dopamine homeostasis.”

Language: Английский

Citations

2
Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CB1 Receptors following Chronic Unpredictable Stress DOI Creative Commons
Εvgenia Dandi, Evangelia Kesidou, Constantina Simeonidou

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 357 - 357

Published: April 3, 2024

Stress-related mental disorders have become increasingly prevalent, thus endangering health worldwide. Exploring stress-associated brain alterations is vital for understanding the possible neurobiological mechanisms underlying these changes. Based on existing evidence, endogenous cannabinoid system (ECS) plays a significant role in stress response, and disruptions its function are associated with neurobiology of various stress-related disorders. This study primarily focuses investigating impact chronic unpredictable (CUS) expression hippocampal type 1 (CB1) receptors, part ECS, adult male female Wistar rats. Additionally, it explores whether environmental enrichment (EE) initiated during adolescence could mitigate CUS-associated CB1 expression. rats, shortly after weaning, were placed either standard housing (SH) or EE conditions duration 10 weeks. On postnatal day 66, specific subgroups SH animals underwent 4-week CUS protocol. Western blot (WB) analysis was conducted whole hippocampus left hemisphere to assess total protein expression, while immunohistochemistry (IHC) performed right estimate receptors certain areas (i.e., CA1, CA3 dentate gyrus-DG). The WB revealed no statistically differences levels among groups; however, reduced found sub-regions using IHC. Specifically, significantly decreased receptor CA1 DG both sexes, whereas decrease limited males. Interestingly, proved protective against reductions. These findings suggest region sex-specific endocannabinoid response stress, emphasizing positive early experiences protection adolescent adverse later life.

Language: Английский

Citations

2
Cannabidiol partially rescues behavioral, neuroinflammatory and endocannabinoid dysfunctions stemming from maternal obesity in the adult offspring DOI
Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 262, P. 110196 - 110196

Published: Oct. 22, 2024

Language: Английский

Citations

1
Post-traumatic stress disorder: molecular mechanisms of the intergenerational and transgenerational inheritance DOI
Е. Л. Паткин, И. О. Сучкова, Sergey G. Tsikunov

et al.

Успехи физиологических наук, Journal Year: 2024, Volume and Issue: 55(4), P. 3 - 26

Published: Dec. 8, 2024

Post-traumatic stress disorder is a mental that closely associated with dysfunction of the hypothalamic-pituitary-adrenal axis, and for its development required experience traumatic event causes negative emotions memories persist quite long time. The likelihood post-traumatic influenced both environmental factors, genetic epigenetic characteristics body. In this case modifications act as dynamic biomarkers (“nanotags”) impact environment on genome (epigenome), which can, under certain conditions, disappear or remain not only in an individual directly exposed to psychogenic trauma, but also transmitted over number generations. Review focuses possible mechanisms intergenerational transgenerational inheritance biological effects stress-related disorders.

Language: Английский

Citations

0