Harnessing nanotechnology for cancer treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Language: Английский

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Radioprotective Effect of Selenium Nanoparticles: A Mini Review

IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 8

Published: Jan. 25, 2024

This study followed the PRISMA reporting guidelines to present results. A comprehensive search was performed on electronic databases such as PubMed, Scopus, Web of Sciences, and Science Direct. Initially, 413 articles were retrieved. After removing duplicates applying specific inclusion exclusion criteria, 10 finally included in this systematic review.

Language: Английский

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A review of bismuth‐based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy

IET Nanobiotechnology, Journal Year: 2023, Volume and Issue: 17(4), P. 302 - 311

Published: May 4, 2023

Abstract About 50% of cancer patients receive radiation therapy. Despite the therapeutic benefits this method, toxicity in normal tissues is unavoidable To improve quality therapy, addition to other methods such as IMRT, IGRT, and high dose, nanoparticles have shown excellent potential when ionising applied target volume. Recently, bismuth‐based (BiNPs) become particularly popular therapy due their atomic numbers (Z), X‐ray attenuation coefficient, low toxicity, cost. Moreover, it easy synthesise a variety sizes shapes. This study aimed review effects NP its combination with compounds, synergies radiotherapy, discussed based on physical, chemical, biological interactions. Targeted non‐targeted NPs used radiotherapy radiosensitizers dose enhancement are described. The results reported literature were categorised into various groups. Also, has highlighted importance different forms treatment find highest efficiency for applying them suitable candidate future clinical applications.

Language: Английский

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Bi₂W₂O₉ Nanoflakes Synthesized via a Hydrothermal Method: Antibacterial Potency and Cytotoxicity Evaluation on Human Dermal Fibroblasts

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5468 - 5477

Published: Feb. 5, 2025

The prevalence of disease and death caused by pathogenic microbes is on the rise, increasing rates antibiotic resistance are concerning. This study investigates antibacterial properties cell viability (NHDF) behavior synthesized Bi2W2O9 nanoflakes. nanoflakes were using hydrothermal method, their physical compositional stability was analyzed through various characterization techniques, including X-ray diffraction (XRD), photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Raman, DRS-UV. demonstrated promising properties, with no significant cytotoxic effects, such as or detachment, observed. confirms that exhibit activity against oral pathogens while maintaining 90% in normal human dermal fibroblast lines, paving way for new therapeutic options treatment infections.

Language: Английский

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Targeted bismuth-based materials for cancer

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The use of bismuth and its compounds in biomedicine has developed rapidly recent years. Due to their unique properties, there are great opportunities for the development new non-invasive strategies early diagnosis effective treatment cancers. This perspective highlights key fabrication methods generate well-defined clinically relevant materials varying characteristics. On one hand, this opens up a wide range possibilities unimodal multimodal imaging. other strategies, which increasingly based on combinatorial therapies, given deal attention. One biggest challenges remains selective tumour targeting, whether active or passive. Here we present an overview developments moving forward from simple enrichment at site via uptake by mononuclear phagocytic system (MPS) more specific targeting covalent modification with tumour-seeking molecules either small antibody-derived molecules.

Language: Английский

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Secondary electron dynamics in core–shell–satellite nanoparticles: a computational strategy for targeted cancer treatment

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Influence of Fe : Au ratio on the dynamics secondary electrons with varying configuration 3 O 4 –SiO 2 –Au nanoparticles for cancer X-ray therapy was investigated.

Language: Английский

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Evaluation of the Impact of Energy, Radiation Type, and Concentration on Dose Enhancement by Gold Nanoparticles

Cancer Treatment and Research Communications, Journal Year: 2025, Volume and Issue: 43, P. 100933 - 100933

Published: Jan. 1, 2025

Language: Английский

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Vaginal Ovule Loaded with Bismuth Lipophilic Nanoparticles and Cetylpyridinium Chloride Inhibits Human Cervical Carcinoma and Candida albicans Growth

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 206 - 206

Published: July 25, 2024

Bismuth lipophilic nanoparticles (BisBAL NPs) and cetylpyridinium chloride (CPC) are antineoplastic antimicrobial in vitro. As a next pre-clinical step, clinically viable dosage form for vaginal application was developed. Compendial pharmacopeial tests (mass uniformity, disintegration, compressive mechanics) inductively coupled plasma optical emission spectroscopy were conducted on in-house developed glycerinated gelatin (60:15

Language: Английский

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Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(11)

Published: July 25, 2024

Radiotherapy (RT), which is a therapeutic treatment modality that commonly used for cancer, employs high‐energy irradiation to induce the generation of reactive oxygen species (ROS) and cause DNA damages. Nevertheless, efficacy RT predominantly constrained due inadequate damage in malignancies deleterious impacts on healthy tissues. In current study, bovine serum albumin (BSA)–coated AgBiS 2 nanodots, also known as @ BSA were developed enhanced breast cancer treatment. This was accomplished by use an extremely simple eco‐friendly method. Both scanning transmission electron microscopy (STEM) (SEM) images revealed prepared nanoradiosensitizers, BSA, spherical shape uniformly distributed. nanodots possessed excellent biocompatibility exhibit monodispersity well. Furthermore, vitro assays such MTT, colony formation assay, intracellular ROS assay significant cell inhibitory impact produced under X‐ray irradiation. Remarkably, combined administration along with increased level within cells increasing localized radiation dosage improving anti‐tumor effectiveness RT.

Language: Английский

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Red blood membrane camouflaging Bismuth nanoflowers designed for radio-photothermal therapy in lung cancer

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(5), P. 544 - 556

Published: March 12, 2024

Radio-photothermal therapy is an effective modality for cancer treatment. To overcome the radio-resistance in hypoxic microenvironment and improve sensitivity of radiotherapy, metal nanoparticles, radio-photothermal are widely used research improving curative effect reducing side effects radiotherapy. Here, we developed red blood membrane camouflaging bismuth nanoflowers (RBCM-BNF) with outstanding physiological stability biodegradability lung tumours. In vitro data proved that RBCM-BNF had greatest cell-killing ability combined X-ray irradiation photo-thermal Meanwhile, vivo studies revealed can alleviate promote tumour cell apoptosis by inhibiting HIF-1α expression increasing caspase-3 expression. Therefore, a good radio-sensitising might be promising biomimetic nanoplatform as therapeutic target cancer.

Language: Английский

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