Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Fibrosis
is
the
final
common
pathology
of
most
chronic
diseases
as
seen
in
heart,
liver,
lung,
kidney,
and
skin
contributes
to
nearly
half
death
developed
countries.
Fibrosis,
or
scarring,
mainly
characterized
by
transdifferentiation
fibroblasts
into
myofibroblasts
excessive
accumulation
extracellular
matrix
(ECM)
secreted
myofibroblasts.
Despite
immense
efforts
made
field
organ
fibrosis
over
past
decades
considerable
understanding
occurrence
development
gained,
there
still
lack
an
effective
treatment
for
fibrotic
diseases.
Therefore,
identifying
a
new
therapeutic
strategy
against
unmet
clinical
need.
Naringenin,
flavonoid
that
occurs
naturally
citrus
fruits,
has
been
found
confer
wide
range
pharmacological
effects
including
antioxidant,
anti-inflammatory,
anticancer
benefits
thus
potentially
exerting
preventive
curative
on
numerous
In
addition,
emerging
evidence
revealed
naringenin
can
prevent
pathogenesis
vivo
vitro
via
regulation
various
pathways
involved
signaling
molecules
such
transforming
growth
factor-β1/small
mother
decapentaplegic
protein
3
(TGF-β1/Smad3),
mitogen-activated
kinase
(MAPK),
phosphatidylinositol
3-kinase/protein
B
(PI3K/Akt),
sirtuin1
(SIRT1),
nuclear
factor-kappa
(NF-κB),
reactive
oxygen
species
(ROS).
Targeting
these
profibrotic
could
become
novel
approach
management
disorders.
this
review,
we
present
comprehensive
summary
antifibrotic
roles
their
underlying
mechanisms
action.
As
food
derived
compound,
may
serve
promising
drug
candidate
Journal of Histochemistry & Cytochemistry,
Journal Year:
2019,
Volume and Issue:
67(9), P. 643 - 661
Published: May 22, 2019
Kidney
fibrosis
is
the
common
histological
end-point
of
progressive,
chronic
kidney
diseases
(CKDs)
regardless
underlying
etiology.
The
hallmark
renal
fibrosis,
similar
to
all
other
organs,
pathological
deposition
extracellular
matrix
(ECM).
Renal
ECM
a
complex
network
collagens,
elastin,
and
several
glycoproteins
proteoglycans
forming
basal
membranes
interstitial
space.
Several
functions
beyond
providing
scaffold
organ
stability
are
being
increasingly
recognized,
for
example,
in
inflammation.
composition
determined
by
function
each
compartments
kidney,
that
is,
glomeruli,
tubulo-interstitium,
vessels.
dynamic
structure
undergoing
remodeling,
particularly
during
fibrosis.
From
clinical
perspective,
proteins
directly
involved
rare
indirectly
CKD
progression
could
serve
as
specific
non-invasive
biomarkers
scaffolds
regenerative
medicine.
gold
standard
currently
only
means
measure
biopsy,
but
new
diagnostic
approaches
appearing.
Here,
we
discuss
localization,
function,
remodeling
major
components
healthy
diseased,
fibrotic
kidneys
potential
use
diagnostics
tissue
engineering.
EBioMedicine,
Journal Year:
2018,
Volume and Issue:
31, P. 217 - 225
Published: May 1, 2018
Renal
fibrosis
is
widely
considered
a
common
mechanism
leading
to
end-stage
renal
failure.
Epithelial-to-mesenchymal
transition
(EMT)
plays
important
roles
in
the
pathogenesis
of
fibrosis.
Runt-related
transcription
factor
1(RUNX1)
vital
role
hematopoiesis
via
Endothelial-to-Hematopoietic
Transition
(EHT),
process
that
conceptually
similar
EMT,
but
its
EMT
and
unclear.
Here,
we
demonstrate
RUNX1
overexpressed
processes
TGF-β-induced
partial
expression
level
SMAD3-dependent.
Knockdown
attenuated
both
phenotypic
changes
levels
marker
genes
tubular
epithelial
cells
(RTECs).
In
addition,
overexpression
promoted
cells.
Moreover,
by
increasing
PI3K
subunit
p110δ,
which
mediated
Akt
activation.
Specific
deletion
Runx1
mouse
RTECs
fibrosis,
was
induced
unilateral
ureteral
obstruction
(UUO)
folic
acid
(FA)
treatment.
These
findings
suggest
potential
target
for
preventing
