Antifibrotic and Antioxidant Effects of a Tetrahedral Framework Nucleic Acid-Based Chlorogenic Acid Delivery System DOI
Lan Yao, Jiajie Li, Xin Qin

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(4), P. 1153 - 1163

Published: March 13, 2023

Liver fibrosis, an early stage of cirrhosis, with large number patients and seriously endangering health, has no viable treatment available currently. In this study, we choose tetrahedral framework nucleic acid nanoparticles as carriers to deliver the polyphenolic monomer chlorogenic injured liver for first time. This delivery system enhanced bioavailability stability acid, laying foundation its antifibrotic antioxidant effects. Our findings show that approach can reduce fibrosis by down-regulating Smad2/3 phosphorylation, limiting extracellular matrix synthesis, substantially improving performance mouse livers restoring normal function; besides, promote reactive oxygen species consumption upregulating Nrf2, regulating oxidative stress alleviating multiorgan damage in mice. general, created a nanodelivery associated providing more possibilities clinical application small molecule drugs.

Language: Английский

SOX12 Facilitates Hepatocellular Carcinoma Progression and Metastasis through Promoting Regulatory T‐Cells Infiltration and Immunosuppression DOI Creative Commons
Xiangyuan Luo, Wenjie Huang, Siwen Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Despite the success of immunotherapy in treating hepatocellular carcinoma (HCC), HCC remains a severe threat to health. Here, crucial transcription factor, SOX12, is revealed that induces immunosuppression liver tumor microenvironment. Overexpressing SOX12 syngeneic models increases intratumoral regulatory T-cell (Treg) infiltration, decreases CD8

Language: Английский

Citations

7
NGF and BDNF in pediatrics syndromes DOI
Giampiero Ferraguti, Sergio Terracina, Ginevra Micangeli

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 145, P. 105015 - 105015

Published: Dec. 21, 2022

Language: Английский

Citations

28
SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation DOI
David N. Hanna, Paula Marincola Smith, Sergey V. Novitskiy

et al.

Gastroenterology, Journal Year: 2022, Volume and Issue: 163(5), P. 1334 - 1350.e14

Published: July 19, 2022

Language: Английский

Citations

27
From the updated landscape of the emerging biologics for IBDs treatment to the new delivery systems DOI
Jiaojiao Yang,

Dingwei Li,

Mengjiao Zhang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 568 - 591

Published: Aug. 15, 2023

Language: Английский

Citations

16
Antifibrotic and Antioxidant Effects of a Tetrahedral Framework Nucleic Acid-Based Chlorogenic Acid Delivery System DOI
Lan Yao, Jiajie Li, Xin Qin

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(4), P. 1153 - 1163

Published: March 13, 2023

Liver fibrosis, an early stage of cirrhosis, with large number patients and seriously endangering health, has no viable treatment available currently. In this study, we choose tetrahedral framework nucleic acid nanoparticles as carriers to deliver the polyphenolic monomer chlorogenic injured liver for first time. This delivery system enhanced bioavailability stability acid, laying foundation its antifibrotic antioxidant effects. Our findings show that approach can reduce fibrosis by down-regulating Smad2/3 phosphorylation, limiting extracellular matrix synthesis, substantially improving performance mouse livers restoring normal function; besides, promote reactive oxygen species consumption upregulating Nrf2, regulating oxidative stress alleviating multiorgan damage in mice. general, created a nanodelivery associated providing more possibilities clinical application small molecule drugs.

Language: Английский

Citations

15