Internal and Emergency Medicine, Journal Year: 2024, Volume and Issue: 19(7), P. 1977 - 1986
Published: July 31, 2024
Language: Английский
Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2177 - 2177
Published: Aug. 29, 2023
The gut microbiota represents a community of microorganisms (bacteria, fungi, archaea, viruses, and protozoa) that colonize the are responsible for mucosal structural integrity immune metabolic homeostasis. relationship between microbiome human health has been intensively researched in past years. It is now widely recognized microbial composition highly general host. Among diseases have linked to an altered population diarrheal illnesses functional constipation. capacity probiotics modulate population, strengthen intestinal barrier, system together with their antioxidant properties encouraged research probiotic therapy many gastrointestinal afflictions. Dietary lifestyle changes use seem play important role easing constipation effectively alleviating diarrhea by suppressing germs involved. This review aims describe how bacteria specific strains could interfere bring benefits as associated treatment
Language: Английский
Citations
31
Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: April 1, 2024
Language: Английский
Citations
15
Medicina, Journal Year: 2024, Volume and Issue: 60(1), P. 108 - 108
Published: Jan. 6, 2024
Slow transit constipation (STC) has an estimated prevalence of 2–4% the general population, and although it is least prevalent chronic phenotypes, more commonly causes refractory symptoms associated with significant psychosocial stress, poor quality life, high healthcare costs. This review provides overview pathophysiology, diagnosis, management options in STC. STC occurs due to colonic dysmotility thought be a neuromuscular disorder colon. Several pathophysiologic features have been observed STC, including reduced contractions on manometry, delayed emptying studies, numbers interstitial cells Cajal histology, amounts excitatory neurotransmitters within myenteric plexuses. The underlying aetiology uncertain, but autoimmune hormonal mechanisms hypothesised. Diagnosing may challenging, there substantial overlap other clinical phenotypes. Prior making diagnosis primary phenotypes secondary need ruled out. An assessment time required for can performed by number different methods. There are several constipation, lifestyle, dietary, pharmacologic, interventional, surgical. effectiveness available therapies differs from that prokinetics often make up mainstay those who fail standard laxatives. few patients medically respond well surgical intervention. common condition burden disease. It present challenge, structured approach great value clinician. many therapeutic available, some having benefits than others.
Language: Английский
Citations
10
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139423 - 139423
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Chromatography B, Journal Year: 2025, Volume and Issue: unknown, P. 124576 - 124576
Published: March 1, 2025
Language: Английский
Citations
1
Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 39(9), P. 1737 - 1744
Published: May 23, 2024
Abstract Neuroendocrine tumors (NETs) are a group of well‐differentiated heterogeneous neoplasms characterized by slow progression and distinct clinical biological behavior. In the majority patients with NET, first‐line treatment is represented somatostatin analogs (SSAs) that, despite being drugs high tolerability (even at doses) providing to carcinoid symptoms control anti‐proliferative effects, may present some side potential impact on quality life nutritional status. The most frequent effects gastrointestinal events in particular alterations bowel habits (diarrhea constipation), abdominal pain, exocrine pancreatic insufficiency, cholelithiasis. Considering relative rarity NETs, literature about frequency standard management adverse SSA‐related still lacking heterogeneous. aim this review arm gastroenterologists other physicians treating NET essential knowledge SSAs. By identifying managing these early, healthcare professionals can offer optimal care, avert foreseeable complications, ensure best outcomes for patients. Without such early recognition, there risk diminishing patient's their ability sustain over time.
Language: Английский
Citations
5
Therapeutic Advances in Gastroenterology, Journal Year: 2024, Volume and Issue: 17
Published: Jan. 1, 2024
Stimulant laxatives are well established as first- or second-line treatments for constipation and although they have a reliable therapeutic effect, alleged safety concerns still exist, particularly with long-term use. The potential harmful effects on the gastrointestinal system (including carcinogenicity) of use diphenylmethane [bisacodyl, sodium picosulfate (SPS)] senna stimulant were assessed in comprehensive review publications identified literature searches performed PubMed Embase up to including June 2023. We reviewed 43 interest. While at supratherapeutic doses been shown cause structural alterations surface absorptive cells animals humans, these reversible not considered clinically relevant. No formal studies demonstrated morphological changes enteric neural elements intestinal smooth muscle bisacodyl SPS humans. Furthermore, there is no convincing evidence that associated development colon cancer, fact, chronic itself has reported potentially increase risk therefore, might reduce this risk. Many suggesting possible effect from limited by their failure consider confounding factors such concomitant neurological disease, metabolic disorders, age. These findings highlight lack colon, thus, benefits treatment laxatives, even long-term, should be reconsidered management patients constipation.
Language: Английский
Citations
5
Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: 69(4), P. 1302 - 1317
Published: March 2, 2024
Language: Английский
Citations
4
Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Intestinal barrier function lies at a critical interface of range peripheral and central processes that influence disorders gut-brain interactions (DGBI). Although rigorously tested, the role dysfunction in driving clinical phenotype DGBI remains to be fully elucidated. In vitro, vivo, ex vivo strategies can test various aspects broader permeability mechanisms gut. Luminal mediators host, bacterial, dietary origin disrupted also luminal milieu. Critical our understanding is how influenced by stress other comorbidities associate with crosstalk between neural, hormonal, immune responses. Additionally, microbiome's significant communication brain gut has led integrative model microbiome axis reciprocal networks composed multiple cells gut, including cells, enterochromaffin microbiota derived mediators. This review highlights techniques for assessment function, appraises evidence mechanistic studies humans, as well provides an overview therapeutic used directly or indirectly restore patients.
Language: Английский
Citations
4
Published: Jan. 1, 2025
Language: Английский
Citations
0