Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 23, 2024

Cannabinoid hyperemesis syndrome presents as a complex of symptoms and signs encompassing nausea, vomiting, abdominal pain, hot water bathing behavior, most typically in heavy cannabis user. Its presentation is frequently associated with hypothalamic-pituitary-adrenal axis activation stress weight loss. Recent investigation has identified five statistically significant mutations patients distinct from those frequent users who lack the symptoms, affecting TRPV1 receptor, two dopamine genes, cytochrome P450 2C9 enzyme that metabolizes tetrahydrocannabinol, adenosine triphosphate-binding cassette transporter. The escalating intake high potency cannabis, or alternatively, other agonists cannabinoid-1 receptor including synthetic cannabinoids. Some develop environmental triggers scents foods suggest classical conditioned responses. Various alternative “causes” are addressed refuted text, exposure to pesticides, neem oil azadirachtin. Nosological confusion cannabinoid arisen cyclic vomiting syndrome, whose pathophysiology clearly distinct. possible utilization non-intoxicating antiemetic components for treatment addressed, along future research suggestions relation its genetic foundation metabolomic signatures.

Language: Английский