Is the microbiome important in celiac disease?
Journal of the Canadian Association of Gastroenterology,
Journal Year:
2025,
Volume and Issue:
8(Supplement_2), P. S51 - S55
Published: Feb. 21, 2025
Abstract
Celiac
disease
(CeD)
is
an
autoimmune
condition
driven
by
gluten
in
genetically
predisposed
individuals.
CeD
characterized
small
intestinal
villous
atrophy
but
presents
with
a
spectrum
of
gastrointestinal
and
systemic
manifestations.
Its
only
treatment
strict,
life-long
adherence
to
gluten-free
diet,
which
difficult
manage
does
not
always
lead
symptomatic
or
mucosal
recovery.
About
40%
the
population
express
CeD-associated
risk
genes,
1%-2%
worldwide
has
CeD.
This,
along
rising
prevalence
suggests
other
cofactors
pathogenesis.
The
gut
microbiome
been
implicated
based
on
epidemiology
studies
clinical
associations.
Mechanistic
using
relevant
vitro
vivo
preclinical
models
have
begun
elucidate
mechanisms
through
microbes
can
influence
Ultimately,
better
understanding
these
their
will
provide
rationale
intervention
strategies
novel
therapeutic
targets
prevent
treat
Language: Английский
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease
Cell Reports,
Journal Year:
2024,
Volume and Issue:
43(4), P. 114045 - 114045
Published: April 1, 2024
Autoantibodies
against
the
enzyme
transglutaminase
2
(TG2)
are
characteristic
of
celiac
disease
(CeD),
and
TG2-specific
immunoglobulin
(Ig)
A
plasma
cells
abundant
in
gut
biopsies
patients.
Here,
we
describe
corresponding
population
autoreactive
B
blood.
Circulating
IgA
present
untreated
patients
on
a
gluten-containing
diet
but
not
controls.
They
clonally
related
to
small
intestinal
cells,
they
express
gut-homing
molecules,
indicating
that
cell
precursors.
Unlike
other
IgA-switched
negative
for
CD27,
placing
them
double-negative
(IgD
Language: Английский
Coeliac disease as a model for understanding multiple sclerosis
Nature Reviews Neurology,
Journal Year:
2024,
Volume and Issue:
20(11), P. 685 - 690
Published: Oct. 8, 2024
Language: Английский
The role of allergen-specific regulatory T cells in the control of allergic disease
Athanasios Stoumpos,
No information about this author
Guido Heine,
No information about this author
Carina Saggau
No information about this author
et al.
Current Opinion in Immunology,
Journal Year:
2024,
Volume and Issue:
92, P. 102509 - 102509
Published: Dec. 6, 2024
Language: Английский
Suboptimal adherence to a gluten-free diet in adults with both type 1 diabetes and celiac disease using urinary gluten immunogenic peptide measurement
Scandinavian Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Dec. 22, 2024
Objectives
Concurrent
type
1
diabetes
(T1D)
and
celiac
disease
(CeD)
pose
challenges
in
insulin
dosage
adjustments
gluten-free
dietary
adherence.
Urine
testing
for
gluten
immunogenic
peptides
(GIP)
is
a
new
method
to
detect
exposure
within
the
last
3–12
h.
Our
aims
were
compare
adherence
between
T1D
+
CeD
individuals
evaluate
urinary
GIP
an
outpatient
setting.
Language: Английский