Long-term risk of chronic liver disease in patients with celiac disease: a nationwide population-based, sibling-controlled cohort study

The Lancet Regional Health - Europe, Journal Year: 2025, Volume and Issue: 50, P. 101201 - 101201

Published: Jan. 9, 2025

SummaryBackgroundCeliac disease (CeD) may be associated with elevated liver enzymes. However, little is known about the risk of chronic (CLD) various etiologies or major adverse outcomes (MALO) in CeD. We aimed to investigate long-term CLD patients CeD.MethodsSwedish nationwide cohort study. identified 48,027 biopsy-confirmed CeD between 1969 and 2017. Each patient was exactly matched ≤5 general population reference individuals (n = 231,909) followed through 2021. Flexible parametric survival models estimated adjusted hazard ratios (aHRs) any specific (i.e., viral hepatitis, metabolic dysfunction-associated steatotic [MASLD], alcohol-related disease, autoimmune disease) MALO (compensated/decompensated cirrhosis, hepatocellular carcinoma, transplantation, liver-related death).FindingsDuring a median follow-up 16.0 years, 649 1571 developed (incidence rate: 79.4 vs. 39.5/100,000 person-years). had higher developing than (aHR 2.01, 95%CI:1.82−2.22). This remained ≥25 years after diagnosis, giving one extra case per 110 until then. Positive associations were present for 4.86), MASLD 2.54), 1.51). Individuals at significantly incident 1.54). Sibling comparisons sensitivity analyses confirmed main findings.InterpretationCeD persistently increased CLD, although absolute low. Physicians should vigilant early signs dysfunction CeD.FundingEuropean Crohn's Colitis Organisation, Swedish Society Medical Research (project#: PG-23-0315-H-02), FORTE 2016-00424), Takeda, Swiss National Science Foundation P500PM_210866).

Language: Английский

---

Effects of a Gluten-Free Diet on Brain Bioelectrical Activity and Neurological Symptoms in Children with Celiac Disease: A Study Using EEG Assessment

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 725 - 725

Published: Jan. 23, 2025

Celiac disease (CeD), also known as gluten enteropathy, is an immune-mediated inflammatory enteropathy triggered by intolerance to gluten. It presents with a spectrum of symptoms, including both gastrointestinal and extraintestinal manifestations, well neurological symptoms. A review the literature indicates that 10–22% patients CeD present The objective this study assess influence gluten-free diet (GFD) on brain bioelectrical activity symptoms in children CeD. Methods: was conducted using multidisciplinary approach, encompassing comprehensive array clinical data gathered alongside laboratory test results, questionnaires, electroencephalogram (EEG) assessments. population included 85 children: 18 newly diagnosed cases (NDC), subsequently reassessed after 6 months GFD celiac (CDD); 27 for over 12 (CDD2); 40 healthy individuals comparison group (CG). Results: observed half NDC exhibited particularly headaches. Following six-month period GFD, there notable reduction symptom severity. In CG, patient higher prevalence abnormalities EEG recordings (p = 0.032), focal sharp waves or slow waves. Conclusions: results demonstrate has positive impact condition improvements correspond normalization, which supports hypothesis dietary intervention plays role mitigating CeD-associated dysfunction.

Language: Английский

---

Immunology in Celiac Disease

Gastrointestinal Endoscopy Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Follow-up of Celiac Disease After Diagnosis

Gastrointestinal Endoscopy Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Gliadin-Rich Diet Worsens Immune and Redox Impairments in Prematurely Aging Mice

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 279 - 279

Published: Feb. 14, 2025

Gliadin is one of the most important fractions gluten, a glycoprotein closely linked to development negative effects on physiological functions and gastrointestinal diseases, such as celiac disease (CD). Research suggests that inadequate stress responses anxiety states may trigger or at least contribute these pathological conditions. Peritoneal leukocytes from Prematurely Aging Mice (PAM), which are chronologically adult mice with compromised anxiety, exhibit functional changes when exposed in vitro gliadin peptides, resembling some immune alterations found also CD patients. This observation prompted us investigate gliadin-rich diet function redox state PAM. In this study, female PAM were fed either gluten-enriched (PAMD, 120 g/kg) standard (PAMC) for four weeks. Immune parameters peritoneal, splenic, thymic (phagocytosis, chemotaxis, Natural Killer activity, lymphoproliferation) markers (glutathione reductase, glutathione peroxidase, reduced/oxidized glutathione, xanthine oxidase lipid peroxidation) evaluated. The results showed PAMD exhibited more impaired function, lower antioxidant enzyme activities, reduced concentrations, well higher oxidized increased activity compared PAMC. These findings suggest worsens impairments PAM, previously described CD, indicating potential animal studying gluten-induced dysregulation.

Language: Английский

---

Purified oat protein can trigger acute symptoms linked to immune activation in coeliac disease patients but not histological deterioration

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333589

Published: Feb. 17, 2025

Background Oat ingestion in coeliac disease (CD) is generally regarded as safe but can trigger enteropathy and T cells specific for oat avenin the gut blood of some individuals. Objective To correlate immune clinical outcomes to oats, purified feeding studies were performed examine symptoms, T-cell immunity intestinal histology CD. Design 33 treated HLA-DQ2.5+ adult CD patients underwent single-bolus or 6-week 3-month whole oats ingestion. cell activation after was measured using serum interleukin 2 (IL-2), a sensitive biomarker gluten-induced symptoms Symptom measures, histology, on duodenum undertaken. Results Among 29 participants, induced dose-dependent 11 (38%) acute 17 (59%). Higher IL-2 levels correlated with more severe symptoms. A single highly symptomatic patient vomited response (1/29; 3%) exhibited striking pro-inflammatory cytokine profile similar wheat-induced responses. Avenin increased frequency CD38-expressing tetramer+integrin β7+ effector memory CD4+ blood, however release tetramer fell following intake no observed. Conclusion Gluten-contamination-free symptom responses usually at level insufficient cause sustained enteropathy. In 1 (3%) triggered wheat-like response, highlighting that minority may need exclude oats. Informed choice regarding important.

Language: Английский

---

Is the microbiome important in celiac disease?

Journal of the Canadian Association of Gastroenterology, Journal Year: 2025, Volume and Issue: 8(Supplement_2), P. S51 - S55

Published: Feb. 21, 2025

Abstract Celiac disease (CeD) is an autoimmune condition driven by gluten in genetically predisposed individuals. CeD characterized small intestinal villous atrophy but presents with a spectrum of gastrointestinal and systemic manifestations. Its only treatment strict, life-long adherence to gluten-free diet, which difficult manage does not always lead symptomatic or mucosal recovery. About 40% the population express CeD-associated risk genes, 1%-2% worldwide has CeD. This, along rising prevalence suggests other cofactors pathogenesis. The gut microbiome been implicated based on epidemiology studies clinical associations. Mechanistic using relevant vitro vivo preclinical models have begun elucidate mechanisms through microbes can influence Ultimately, better understanding these their will provide rationale intervention strategies novel therapeutic targets prevent treat

Language: Английский

---

T cell receptor precision editing of regulatory T cells for celiac disease

Science Translational Medicine, Journal Year: 2025, Volume and Issue: 17(790)

Published: March 19, 2025

Celiac disease, a gluten-sensitive enteropathy, demonstrates strong human leukocyte antigen (HLA) association, with more than 90% of patients carrying the HLA-DQ2.5 allotype. No therapy is available for condition except lifelong gluten-free diet. To address this gap, we explored therapeutic potential regulatory T cells (Tregs). By orthotopic replacement cell receptors (TCRs) through homology-directed repair, generated gluten-reactive HLA-DQ2.5-restricted CD4+ engineered (e) effector (Teffs) and eTregs performed in vivo experiments transgenic mice. Of five validated TCRs, TCRs specific two immunodominant deamidated gluten epitopes (DQ2.5-glia-α1a DQ2.5-glia-α2) were selected further evaluation. eTeffs exposed to oral gavage colocalized dendritic B Peyer's patches gut-draining lymph nodes specifically migrated intestine. The suppressive function correlated high TCR functional activity. one epitope suppressed proliferation gut migration same other epitope, demonstrating bystander suppression. suppression requires an antigen-specific activation given that polyclonal Tregs failed suppress eTeffs. These findings highlight as celiac disease.

Language: Английский

---

Primary biliary cholangitis: Insights into genetic susceptibility and systemic manifestations

European Journal of Inflammation, Journal Year: 2025, Volume and Issue: 23

Published: March 1, 2025

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by damage to small intrahepatic bile ducts. The etiology and pathogenesis of PBC remain unknown. It often considered be related an immunological disorder induced genetics environmental factors. Antimitochondrial antibodies (AMAs) along with specific antinuclear such as gp210 Sp100 are markers the disease. Middle-aged elderly women main patients. clinical manifestations non-specific, which presents fatigue skin itching usually. However, patients gradually develop cholestasis fibrosis, eventually dying progressed cirrhosis failure. Currently, ursodeoxycholic acid (UDCA) treatment choice, recommended for all may coexist other disorders that arise from multiple systems, inflammatory bowel (IBD), Sjögren’s syndrome (SS) type 1 diabetes mellitus (T1DM). causal relationship between extrahepatic diseases (EHAIDs) unclear. This article summarizes new developments in study primary aims provide reference scientific workers field research on this

Language: Английский

---

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopes

Theoretical and Applied Genetics, Journal Year: 2025, Volume and Issue: 138(5)

Published: April 8, 2025

Language: Английский

---