LncRNA LINC01133 Targeting miR-141-5p to Mediate the Progression and Ameliorate Poor Prognosis of Prostate Cancer DOI
Yang Yang Li,

Y. N. Zhang

Russian Journal of Genetics, Journal Year: 2023, Volume and Issue: 59(S2), P. S191 - S198

Published: Dec. 1, 2023

Language: Английский

Node-adaptive graph Transformer with structural encoding for accurate and robust lncRNA-disease association prediction DOI Creative Commons
Guanghui Li,

Peihao Bai,

Liang Cheng

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Jan. 18, 2024

Abstract Background Long noncoding RNAs (lncRNAs) are integral to a plethora of critical cellular biological processes, including the regulation gene expression, cell differentiation, and development tumors cancers. Predicting relationships between lncRNAs diseases can contribute better understanding pathogenic mechanisms disease provide strong support for advanced treatment methods. Results Therefore, we present an innovative Node-Adaptive Graph Transformer model predicting unknown LncRNA-Disease Associations, named NAGTLDA. First, utilize node-adaptive feature smoothing (NAFS) method learn local information nodes encode structural fusion similarity network using Structural Deep Network Embedding (SDNE). Next, module is used capture potential association nodes. Finally, employ with two multi-headed attention layers learning global-level embedding fusion. structure coding added as inductive bias compensate missing message-passing mechanism in Transformer. NAGTLDA achieved average AUC 0.9531 AUPR 0.9537 significantly higher than state-of-the-art methods 5-fold cross validation. We perform case studies on 4 diseases; 55 out 60 associations have been validated literatures. The results demonstrate enormous graph incorporate uncovering lncRNA-disease correlations. Conclusions Our proposed serve highly efficient computational associations.

Language: Английский

Citations

17
Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance DOI Creative Commons
Hanan Elimam, Mohamed Bakr Zaki,

Mai A. Abd‐Elmawla

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Abstract Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate (PCa) is unfavorable since it perilous lethal malignancy. capacity phytochemical nutraceutical chemicals repress oncogenic lncRNAs activate tumor suppressor has garnered significant attention as possible strategy diminish development, proliferation, metastasis, invasion cells. A potential technique treat enhance sensitivity cells existing conventional therapies use phytochemicals anticancer characteristics. Functional studies indicate that modulate drug resistance, stemness, invasion, angiogenesis, proliferation via interactions suppressors oncoproteins. Among them, numerous lncRNAs, such HOTAIR, PlncRNA1, GAS5, MEG3, LincRNA-21, POTEF-AS1, support development PCa through many molecular mechanisms, including modulation regulation various signal pathways like PI3K/Akt, Bax/Caspase 3, P53, MAPK cascade, TGF-β1. Other particular, MALAT-1, CCAT2, DANCR, LncRNA-ATB, ZEB1-AS1, SChLAP1, H19, key players regulating aforementioned processes. Natural substances have shown promising benefits against altering essential signaling pathways. overexpression advanced TNM stage, chemoresistance, reduced LncRNAs possess crucial clinical transitional implications PCa, diagnostic prognostic biomarkers, well medicinal targets. To impede progression beneficial target aberrant long non-coding RNAs using antisense oligonucleotides small interfering (siRNAs). This prevents them from transmitting harmful messages. In summary, several precision medicine approaches may be used rectify dysfunctional lncRNA regulatory circuits, so improving detection eventually facilitating conquest this disease. Due their presence biological fluids tissues, they serve novel biomarkers. Enhancing treatments mitigates resistance chemotherapy radiation.

Language: Английский

Citations

1
Discovery of lncRNA‐Based ProsRISK Score in Serum as Potential Biomarkers for Improved Accuracy of Prostate Cancer Detection DOI Creative Commons

Xiumei Jiang,

Zhongchao Liu, Hongxing Wang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(8)

Published: April 1, 2025

ABSTRACT Circulating lncRNAs have emerged as promising biomarkers for the diagnosis of various cancers. This study aimed to establish an accurate risk prediction model based on serum facilitate detection prostate cancer (PCA). RT‐qPCR was used analyse levels candidate lncRNAs, and four (NEAT1, ARLNC1, FOXP4‐AS1 DSCAM‐AS1) were identified be differently expressed in from 190 PCA patients, 140 benign controls, 170 healthy controls. A ProsRISK score prostate‐specific antigen (PSA) established training set. ROC analysis validation set revealed that demonstrated more powerful capacity discriminating with AUC 0.926 (95% CI: 0.882–0.970) 0.837 0.770–0.904), which significantly higher than those lncRNA panel or PSA alone (all at p < 0.05). Moreover, showed good diagnostic performance I–II patients compared corresponding AUCs 0.905 0.843–0.968) 0.819 0.732–0.907). Our findings indicated constructed could a reliable stratification great potential clinical use improve precision surveillance PCA.

Language: Английский

Citations

0
The potential of sertoli cells (SCs) derived exosomes and its therapeutic efficacy in male reproductive disorders DOI
Narjes Amiri, Paria Mohammadi, Atefeh Allahgholi

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 312, P. 121251 - 121251

Published: Dec. 2, 2022

Language: Английский

Citations

15
Exosomal long noncoding RNAs MAGI2-AS3 and CCDC144NL-AS1 in oral squamous cell carcinoma development via the PI3K-AKT-mTOR signaling pathway DOI
Cuiping Li,

Hejia Guo,

Juan Xiong

et al.

Pathology - Research and Practice, Journal Year: 2022, Volume and Issue: 240, P. 154219 - 154219

Published: Nov. 13, 2022

Language: Английский

Citations

12
A thorough understanding of the role of lncRNA in prostate cancer pathogenesis; Current knowledge and future research directions DOI
Ramin Haghighi, Roxana Yolanda Castillo-Acobo, Ali H. Amin

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154666 - 154666

Published: July 3, 2023

Language: Английский

Citations

6
Implications of c-Myc in the pathogenesis and treatment efficacy of urological cancers DOI
Kiavash Hushmandi, Seyed Hassan Saadat, Mehdi Raei

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 259, P. 155381 - 155381

Published: June 1, 2024

Language: Английский

Citations

2
EGR1/ LINC00839 /SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells DOI Creative Commons

Zunxian Wang,

Bo Wei, Shuxia Ma

et al.

Cancer Biology & Therapy, Journal Year: 2023, Volume and Issue: 24(1)

Published: Oct. 20, 2023

Bladder cancer is one of the most common malignant tumors urinary system, and its incidence increasing worldwide. However, underlying mechanisms that trigger migration, invasion chemotherapy resistance are unclear.Bioinformatics analysis bladder cohort indicated LINC00839 deregulated in cancer. was validated highly expressed patients cell lines. In addition, induced Gemcitabine cells. We identified transcription factor EGR1 directly repressed thereby suppressed migration Furthermore, interacted with miR-142, which subsequently regulated expression SOX5, a well-studied oncogene targeted by miR-142. served as suppressive SOX5. Therefore, or indirectly regulates SOX5 via LINC00839/miR-142 axis. promoting autophagy.EGR1, form coherent feed-forward loop modulates

Language: Английский

Citations

5
BMSC derived EVs inhibit colorectal Cancer progression by transporting MAGI2-AS3 or something similar DOI
Tianyi Ma, Meng Wang, Song Wang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 121, P. 111235 - 111235

Published: May 26, 2024

Language: Английский

Citations

1
Construction of prognostic markers for gastric cancer and comprehensive analysis of pyroptosis-related long non-coding RNAs DOI
Yibin Wang, Di Li,

Jing Xun

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2024, Volume and Issue: 16(7), P. 2281 - 2295

Published: July 22, 2024

China's most frequent malignancy is gastric cancer (GC), which has a very poor survival rate, and the rate for patients with advanced GC dismal. Pyroptosis been connected to genesis development of cancer. The function pyroptosis-related long non-coding RNAs (PRLs) in GC, on other hand, remains uncertain.

Language: Английский

Citations

1