The Redox Stress Test: A novel technique reveals oxidative stress in Parkinson’s disease

Medical Research Archives, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 1, 2024

A novel Redox Stress Test has been developed to identify symptoms of diseases associated with oxidative stress by observing symptom changes induced short-term activation the transcription factor Nrf2, restore redox homeostasis. The Nrf2 pathway is triggered a herbal preparation, Broccoli Seed Tea, deliver therapeutic dose highly bioavailable sulforaphane, potent activator Nrf2. We discuss rationale behind tea and describe methods used optimise bioavailability sulforaphane match pharmacodynamics activation. When consumed people Parkinson’s disease, powerful concurrent attenuation diverse group non-motor symptoms, including fatigue, constipation urinary urgency. Motor were strictly unaffected. This observation indicates that may be common contributing involving sites in CNS peripheral organs. tentatively interpret results terms hypothetical model for Syndrome which we as multisystem disorder reservoirs disease organs well brain. Eliminating therefore prerequisite stopping progression According this model, brain provokes progressive neurological damage, not recognised such early years. More specific only come light many years later, when damage dopaminergic neurons creates dopamine deficiency eventually exceeds threshold required normal motor control, generating new coherent define movement disorder. Given apparent ease can quenched several locations simultaneously, briefly possible implications public health, medical research, patients patient advocacy groups. note have potential explore other where believed play major role, although remains subject validation further research.

Language: Английский

Brokkoli – immer eine zuverlässige Quelle für Glucoraphanin und Sulforaphan?

Lebensmittelchemie, Journal Year: 2024, Volume and Issue: 78(S1)

Published: March 1, 2024