Pursuing Step Economy in Total Synthesis of Complex Marine Macrolide Natural Products DOI Creative Commons
Haruhiko Fuwa

Published: Jan. 1, 2024

Abstract Here I describe our first-, second-, and third-generation synthesis of (+)-neopeltolide, which is a Jamaican marine macrolide that shows potent antiproliferative antifungal activities. The enabled an expedient access to (+)-neopeltolide in 11 linear 23 total steps, so far the shortest this natural product. Convergent planning by taking advantage chemoselective transformations, cross-coupling reactions, tandem reactions was key for increasing step economy.

Language: Английский

Pursuing Step Economy in Total Synthesis of Complex Marine Macrolide Natural Products DOI Creative Commons
Haruhiko Fuwa

Published: Jan. 1, 2024

Abstract Here I describe our first-, second-, and third-generation synthesis of (+)-neopeltolide, which is a Jamaican marine macrolide that shows potent antiproliferative antifungal activities. The enabled an expedient access to (+)-neopeltolide in 11 linear 23 total steps, so far the shortest this natural product. Convergent planning by taking advantage chemoselective transformations, cross-coupling reactions, tandem reactions was key for increasing step economy.

Language: Английский

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