Pharmacokinetic Assessments of Ursolic Loaded-Dendrimer Complex DOI
Aditya Singh, Valeed Ahmad Ansari, Tarique Mahmood

et al.

Current Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 20(7), P. 538 - 556

Published: Aug. 29, 2024

Background: This study investigates the application of polyamidoamine (PAMAM) dendrimers as an innovative drug delivery approach for enhancing pharmacokinetic profile ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA, sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively studied its pharmacological characteristics, including anti-inflammatory, antioxidant, anti-diabetic properties, recognized in Traditional Chinese Medicine (TCM). The clinical utility UA is hampered by low bioavailability, which attributed to hydrophobic nature. To address this limitation, we explore use PAMAM dendrimers, known their potential. Methods: UA-PAMAM G0 were synthesized varying molar ratios. Characterization included size analysis, PDI, zeta potential determination. FTIR confirmed chemical structure. Male SD rats acclimatized administered control suspension UA-G0 dendrimer complex orally. Blood samples collected analysis. obtained IAEC approval. Results: complexes exhibited sizes based on ratios, 2:1 ratio showing significantly smaller dimensions. successful conjugation. In study, demonstrated higher plasma concentrations than alone, indicated increased Cmax AUC values. results suggest enhanced oral bioavailability complex. Conclusion: synthesis variations analysis revealed improved compared alone. These findings highlight compounds bridging gap between traditional herbal medicine modern strategies. Further research can broader applications such systems.

Language: Английский

Sarcopenia as a Risk Factor for Alzheimer’s Disease: Genetic and Epigenetic Perspectives DOI Open Access
Stuart M. Raleigh, Kayleigh J. A. Orchard

Genes, Journal Year: 2024, Volume and Issue: 15(5), P. 561 - 561

Published: April 27, 2024

Sarcopenia, defined as the age-associated loss of muscle mass and increased fragility with age, is increasing worldwide. The condition often precedes development Alzheimer’s disease, thereby decreasing levels mobility physical activity in those affected. Indeed, has, some studies, been associated an risk disease other dementias. However, a detailed understanding interplay between both conditions not available needs to be thoroughly addressed. In following review, we focus on several genes, specifically APOE, BDNF, ACE, FTO, FNDC5, that have conditions. We also discuss epigenetic regulation each these genes along non-coding RNAs (ncRNAs) may role sarcopenic phenotypes. Finally, assert application systems biology will unravel relationship sarcopenia believe prevention older age reduce incidence debilitating cognitive decline.

Language: Английский

Citations

4
“Methyl jasmonate: bridging plant defense mechanisms and human therapeutics” DOI
Garima Sharma,

Badruddeen Badruddeen,

Juber Akhtar

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

0
Biomarkers in Alzheimer’s disease: new frontiers with olfactory models DOI

Shubhrat Maheshwari,

Aditya Vikram Singh,

Amita Verma

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Understanding the Molecular Impact of Physical Exercise on Alzheimer’s Disease DOI Open Access

Alba Cantón-Suárez,

Leticia Sánchez-Valdeón, Laura Bello-Corral

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13576 - 13576

Published: Dec. 18, 2024

Alzheimer’s disease is one of the most common neurodegenerative diseases, characterized by a wide range neurological symptoms that begin with personality changes and psychiatric symptoms, progress to mild cognitive impairment, eventually lead dementia. Physical exercise part non-pharmacological treatments used in disease, as it has been shown delay process improving redox state brain tissue, providing anti-inflammatory effects or stimulating release brain-derived neurotrophic factor enhances structure performance. Here, we reviewed results obtained from studies conducted both animal models human subjects comprehend how physical interventions can exert molecular mechanisms underlying pathophysiological processes disease: amyloid β-peptide pathology, tau neuroglial changes, mitochondrial dysfunction, oxidative stress. seems have protective effect against since induce positive some biomarkers related disease. However, additional humans are necessary address current lack conclusive evidence.

Language: Английский

Citations

2
Pharmacokinetic Assessments of Ursolic Loaded-Dendrimer Complex DOI
Aditya Singh, Valeed Ahmad Ansari, Tarique Mahmood

et al.

Current Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 20(7), P. 538 - 556

Published: Aug. 29, 2024

Background: This study investigates the application of polyamidoamine (PAMAM) dendrimers as an innovative drug delivery approach for enhancing pharmacokinetic profile ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA, sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively studied its pharmacological characteristics, including anti-inflammatory, antioxidant, anti-diabetic properties, recognized in Traditional Chinese Medicine (TCM). The clinical utility UA is hampered by low bioavailability, which attributed to hydrophobic nature. To address this limitation, we explore use PAMAM dendrimers, known their potential. Methods: UA-PAMAM G0 were synthesized varying molar ratios. Characterization included size analysis, PDI, zeta potential determination. FTIR confirmed chemical structure. Male SD rats acclimatized administered control suspension UA-G0 dendrimer complex orally. Blood samples collected analysis. obtained IAEC approval. Results: complexes exhibited sizes based on ratios, 2:1 ratio showing significantly smaller dimensions. successful conjugation. In study, demonstrated higher plasma concentrations than alone, indicated increased Cmax AUC values. results suggest enhanced oral bioavailability complex. Conclusion: synthesis variations analysis revealed improved compared alone. These findings highlight compounds bridging gap between traditional herbal medicine modern strategies. Further research can broader applications such systems.

Language: Английский

Citations

1