Unveiling the cytotoxicity of a new gold(I) complex towards hepatocellular carcinoma by inhibiting TrxR activity DOI Creative Commons
Yuan Wang, Haokun Yuan,

Rui-Qin Fang

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Hepatocellular carcinoma (HCC), the predominant type of liver cancer, is an aggressive malignancy with limited therapeutic options. In this study, we assess a collection newly designed gold(I) phosphine complexes. Remarkably, compound GC002 exhibits greatest toxicity to HCC cells and outperforms established medications, such as sorafenib auranofin, in terms antitumor efficacy. triggers irreversible necroptosis by increasing intracellular accumulation reactive oxygen species (ROS). Mechanistically, significantly suppresses activity thioredoxin reductase (TrxR), which plays crucial role regulating redox homeostasis often overexpressed binding directly enzyme. Our

Language: Английский

Unveiling the cytotoxicity of a new gold(I) complex towards hepatocellular carcinoma by inhibiting TrxR activity DOI Creative Commons
Yuan Wang, Haokun Yuan,

Rui-Qin Fang

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Hepatocellular carcinoma (HCC), the predominant type of liver cancer, is an aggressive malignancy with limited therapeutic options. In this study, we assess a collection newly designed gold(I) phosphine complexes. Remarkably, compound GC002 exhibits greatest toxicity to HCC cells and outperforms established medications, such as sorafenib auranofin, in terms antitumor efficacy. triggers irreversible necroptosis by increasing intracellular accumulation reactive oxygen species (ROS). Mechanistically, significantly suppresses activity thioredoxin reductase (TrxR), which plays crucial role regulating redox homeostasis often overexpressed binding directly enzyme. Our

Language: Английский

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