Brook-Oxidation Reaction of Acylsilanes: General Access to α-Ketoamides and α-Ketothioamides DOI
Danni Yang, Yanan Du, Peng Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(46), P. 10020 - 10024

Published: Nov. 13, 2024

A novel chemoselective Brook-oxidation reaction of acylsilanes initiated by the carbamoyl anion has been successfully developed for first time. This method enables synthesis diverse α-ketoamides and α-ketothioamides under transition metal-free strong oxidant-free conditions with high yields chemoselectivity. It also demonstrates tolerance toward a wide range functional groups. The synthetic utility this process is underscored its successful application in an orexin receptor antagonist from acylsilane, highlighting potential development therapeutic agents further exploration chemistry.

Language: Английский

Transition Metal Promoted Brook Rearrangement and its Related Reactions DOI

Fazhou Yang,

Jinbao Wang, Yujie Dong

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 168, P. 134351 - 134351

Published: Nov. 1, 2024

Language: Английский

Citations

1
Brook-Oxidation Reaction of Acylsilanes: General Access to α-Ketoamides and α-Ketothioamides DOI
Danni Yang, Yanan Du, Peng Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(46), P. 10020 - 10024

Published: Nov. 13, 2024

A novel chemoselective Brook-oxidation reaction of acylsilanes initiated by the carbamoyl anion has been successfully developed for first time. This method enables synthesis diverse α-ketoamides and α-ketothioamides under transition metal-free strong oxidant-free conditions with high yields chemoselectivity. It also demonstrates tolerance toward a wide range functional groups. The synthetic utility this process is underscored its successful application in an orexin receptor antagonist from acylsilane, highlighting potential development therapeutic agents further exploration chemistry.

Language: Английский

Citations

0