Thrombosis and Haemostasis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 20, 2025
Abstract
Patient
care
pathways
provide
an
integrated
approach
to
atrial
fibrillation
(AF)
management.
International
guidelines
propose
various
patient
pathways,
each
emphasizing
different
strategies
for
assessing
stroke
and
bleeding
risk.
Due
ethnicities
susceptibility
or
risk,
caution
should
be
taken
during
application
of
Western
cohorts-derived
Asian
cohorts.
Evidence-based
rather
than
eminence-based
adopted
AF
care.
In
this
clinical
focus,
we
summarize
compare
using
evidence
on
the
implementation
in
real-world
registries,
risk
across
non-Asian
guidelines.
European Journal of Clinical Investigation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Background
Coronary
artery
disease
(CAD)
and
atrial
fibrillation
(AF)
often
coexist,
but
the
impact
of
clinical
phenotypes
CAD
on
outcomes
in
AF
patients
non‐vitamin
K
antagonist
oral
anticoagulant
drugs
(NOACs)
era
is
less
well
understood.
Methods
This
was
a
post‐hoc
GLORIA‐AF
registry,
global,
multicenter,
prospective
registry
study.
Patients
were
divided
into
three
groups:
prior
history
myocardial
infarction
(MI)/unstable
angina
group
(Group
1);
stable
2);
control
without
or
MI/unstable
angina.
The
primary
endpoint
composite
all‐cause
death
stroke,
safety
major
bleeding.
Results
A
total
24,827
included
this
analysis
(median
age
71
(IQR,
64–78)
years;
55%
male)
5394
(21.7%)
had
CAD.
During
follow‐up
2
years,
incidence
5.99
(95%
CI,
5.33,
6.71)
per
100
patient‐years
Group
1,
4.04
3.55,
4.70)
2,
2.79
2.62,
2.96)
(
p
<
.001).
Compared
group,
adjusted
hazard
ratio
Groups
1
1.58
1.37,
1.83,
.001)
1.22
1.04,
1.43,
=
.012),
respectively.
Among
anticoagulated
with
CAD,
NOACs
associated
reduced
risk
bleeding,
compared
vitamin
antagonists
(VKA).
Conclusions
prevalent
AF,
influenced
being
significantly
increased
CV
events,
to
superior
VKA
terms
effectiveness
concomitant
BMC Cardiovascular Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
The
aim
of
this
study
was
to
explore
the
correlation
between
blood
test
indicators
and
Atrial
Fibrillation
(AF)
in
Individuals
Aged
65
Older
Yangzhou,
Jiangsu.
From
January
1,
2019,
August
31,
2023,
an
epidemiological
cross-sectional
survey
conducted
among
elderly
population
undergoing
health
check-ups
at
Northern
Jiangsu
People's
Hospital
Province.
Patients
diagnosed
with
AF
after
a
12-lead
electrocardiogram
were
included
case
group,
non-AF
individuals
matched
by
age
gender
1:4
frequency
ratio
control
group.
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
regression
used
select
important
variables
from
routine
tests
biochemical
their
derived
(such
as
TyG,
TyG-BMI,
TG/HDL-c,
RAR,
NLR,
MHR).
Based
on
selected
variables,
participants
divided
into
four
groups
(Q1
~
Q4),
multifactorial
Logistic
analysis,
restricted
cubic
spline
regression,
subgroup
analysis
Receiver
Operating
Characteristic
(ROC)
curve
relationship
relevant
AF.
A
total
5,879
over
study,
prevalence
2.96%
(174/5,879).
overall
population,
well
male
female
populations,
showed
continuous
increasing
trend
(P
for
<
0.001).
696
without
matching
served
LASSO
identified
albumin,
direct
bilirubin,
uric
acid
three
significant
indicators.
After
adjusting
confounding
factors,
lower
levels
higher
bilirubin
significantly
associated
occurrence
0.05).
Gender
revealed
that
albumin
not
>
0.05),
while
In
Restricted
nonlinear
ROC
indicates
all
have
good
association
strength
patients,
showing
strongest
effect
(AUC
(95%
CI)
=
0.728
(0.686,
0.769)).
Low
high
are
Central
region.
conclusions
need
further
validation
larger
sample
size.
Expert Review of Cardiovascular Therapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Dynamic
reassessment
of
stroke
and
bleeding
risks
is
a
cornerstone
patient-centered
care
in
atrial
fibrillation
(AF)
management.
Unlike
traditional
approaches
that
evaluate
these
only
at
diagnosis
or
initiation
oral
anticoagulation,
current
evidence
emphasizes
periodic
due
to
the
evolving
nature
risks.
Stroke
AF
patients
are
influenced
by
aging,
new
comorbidities,
worsening
health
conditions,
requiring
updates
management
plans
optimize
outcomes.
increases
CHA2DS2-VASc
(or
sex-less
CHA2DS2-VA)
HAS-BLED
scores
associated
with
heightened
bleeding,
underscoring
need
for
regular
reassessment.
Addressing
modifiable
risk
factors
such
as
hypertension,
renal
dysfunction,
concurrent
medications
key
improving
Although
several
guidelines
now
recommend
least
annually,
optimal
timing
remains
unclear.
Evidence
supports
more
frequent
reassessments
low-risk
(every
4
months)
high-risk
(within
4-6
weeks)
promptly
identify
changes
intervention.
Despite
its
benefits,
challenges
remain
regarding
reassessment,
including
lack
universally
applicable
intervals
complexity
multidisciplinary
evaluations.
Future
advancements
artificial
intelligence
tools
expected
enhance
enabling
precise,
personalized,
dynamic
patient
Internal and Emergency Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 27, 2025
Abstract
The
current
Atrial
fibrillation
Better
Care
(ABC)
pathway
for
holistic
or
integrated
management
of
AF
is
associated
with
improved
clinical
outcomes;
however,
data
on
the
very
elderly
(aged
≥
85
years)
are
sparse.
To
evaluate
impact
ABC
outcomes
amongst
patients
over
a
follow-up
period
1
year.
ChiOTEAF
registry
prospective,
multicenter
nationwide
study
conducted
from
October
2014
to
December
2018.
Endpoints
interest
were
composite
outcome
all-cause
death/any
thromboembolism
(TE),
death,
TE
events,
and
major
bleeding.
eligible
cohort
included
1215
individuals
(mean
age
88.5
±
3.3;
33.5%
female),
which
142
(11.7%)
managed
accordingly
pathway.
compliance
was
independently
lower
odds
(odds
Ratio
(OR):
0.23;
95%
confidence
interval
(CI):
0.08–0.66)
death
(OR:
0.22;
CI:
0.07–0.75),
without
significant
increase
in
bleeding
compared
non-compliance.
Health-related
quality
life
(QOL)
also
significantly
higher
compliant
group
non-compliant
(EQ
score
0.83
0.17
vs.
0.78
0.20;
p
=
0.004).
Independent
predictors
non-compliance
prior
bleeding,
chronic
kidney
disease,
dementia.
Our
findings
suggest
that
adherence
survival
health-related
QOL.
