Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 498 - 498

Published: April 20, 2025

Advanced glycation end-products (AGEs) cause blood vessel damage and induce diabetic complications in various organs, such as the eyes, kidneys, nerves, skin. As stress causes aesthetic, physical, functional changes skin, glycation-targeting skin anti-aging strategies are attracting attention cosmetology dermatology. The primary goal of this review is to understand significance glycation-induced aging examine therapeutic potential strategies. This study covers experimental clinical studies exploring interventions attenuate aging. Glycation decreases viability cells culture media, cell-mediated contraction collagen lattices reconstructed models, expression fibrillin-1 at dermo-epidermal junction explants. It also increases cross-links tail tendon animals, prolonging its breakdown time. However, these attenuated by several synthetic natural agents. Animal have shown that dietary or topical administration agents with antiglycation antioxidant activity can AGE levels (measured autofluorescence) parameters (e.g., color, wrinkles, elasticity, hydration, dermal density) induced chronological aging, diabetes, high-carbohydrate diets, ultraviolet radiation, oxidative stress. Therefore, accumulating evidence supports supplements formulations containing one more may help mitigate AGEs.

Language: Английский