Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(23)
Published: April 4, 2024
Abstract
The
present
study
reports
an
unprecedented
protocol
for
the
phosphonylation
of
unactivated
C(sp
3
)−H
bonds.
By
utilizing
1
mol
%
4DPAIPN
(1,2,3,5‐tetrakis(diphenylamino)‐4,6‐dicyanobenzene)
as
catalyst,
satisfactory
yields
γ‐phosphonylated
amides
are
obtained
through
a
visible‐light‐induced
reaction
between
N
‐((4‐cyanobenzoyl)oxy)alkanamides
and
9‐fluorenyl
o
‐phenylene
phosphite
at
room
temperature.
This
demonstrates
broad
substrate
scope
wide
functional
group
compatibility.
Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
363(7), P. 1810 - 1834
Published: Feb. 16, 2021
Abstract
Transition
metal‐catalysed
processes
have
been
widely
used
for
the
functionalization
of
inert
C−H
bonds.
Strategies
benzylic
position
having
a
relatively
weak
bond
(bond
dissociation
energy∼
80–90
kcal/mol)
differ
from
aliphatic
and
aromatic
positions
with
stronger
The
recent
advances
in
direct
activation
through
generation
C(
sp
3
)
radicals
demonstrated
potential
electrochemistry
photochemistry
as
means
constructing
new
chemical
This
review
will
cover
progress
organic
radical
strategies
employing
sustainable
tools.
In
addition,
mechanistic
details
typical
reactions
included
which,
turn,
help
researchers
to
look
at
this
promising
area
different
perspective
towards
discoveries
often
hidden
opportunities.
magnified
image
The Chemical Record,
Journal Year:
2021,
Volume and Issue:
21(9), P. 2585 - 2600
Published: April 8, 2021
Progress
in
electroorganic
synthesis
is
linked
to
innovation
of
new
synthetic
reactions
with
impact
on
medicinal
chemistry
and
drug
discovery
the
desire
minimise
waste
provide
energy-efficient
chemical
transformations
for
future
industrial
processes.
Paired
electrosynthetic
processes
that
combine
use
both
anode
cathode
(convergent
or
divergent)
minimal
(or
without)
intentionally
added
electrolyte
need
additional
reagents
are
growing
interest.
In
this
overview,
recent
progress
developing
paired
electrolytic
surveyed.
The
discussion
focuses
electrosynthesis
technology
proven
value
preparation
small
molecules.
Reactor
types
contrasted
concept
translating
light-energy
driven
photoredox
into
highlighted
as
a
newly
emerging
trend.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(12), P. 7907 - 7975
Published: May 29, 2024
The
increasing
importance
of
azaheterocyclic
phosphonates
in
the
agrochemical,
synthetic,
and
medicinal
field
has
provoked
an
intense
search
development
synthetic
routes
for
obtaining
novel
members
this
family
compounds.
This
updated
review
covers
methodologies
established
since
2004,
focusing
on
synthesis
phosphonates,
which
phosphonate
moiety
is
directly
substituted
onto
to
structure.
Emphasizing
recent
advances,
classifies
newly
developed
approaches
according
ring
size
providing
information
biological
activities
whenever
available.
Furthermore,
summarizes
various
methods
formation
C–P
bonds,
examining
sustainable
such
as
Michaelis–Arbuzov
reaction,
Michaelis–Becker
Pudovik
Hirao
coupling,
Kabachnik–Fields
reaction.
After
analyzing
applications
investigated
years,
a
predominant
focus
evaluation
these
compounds
anticancer
agents
evident.
emerging
underline
versatility
potential
compounds,
highlighting
need
continued
research
expand
interesting
family.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 770 - 797
Published: April 16, 2025
In
this
review,
we
describe
recent
advances
in
electrochemical
green
methods
for
the
synthesis
of
various
organophosphorus
compounds
through
formation
phosphorus–carbon,
phosphorus–nitrogen,
phosphorus–oxygen,
phosphorus–sulfur,
and
phosphorus–selenium
bonds.
The
impact
different
electrodes
is
also
discussed
matter.
Graphite,
platinum,
RVC,
nickel
have
been
used
extensively
compounds.
made
method
a
promising
preparing
structures.
This
review
an
introduction
to
encourage
scientists
use
electrosynthesis
as
green,
precise,
low-cost
prepare
phosphorous
Frontiers in Chemistry,
Journal Year:
2022,
Volume and Issue:
10
Published: Nov. 3, 2022
The
activation
of
C–H
bond,
and
its
direct
one-step
functionalization,
is
one
the
key
synthetic
methodologies
that
provides
access
to
a
variety
practically
significant
compounds.
Particular
attention
focused
on
modifications
obtained
at
final
stages
synthesis
complicated
molecules,
which
requires
high
tolerance
presence
existing
functional
groups.
Phosphorus
an
indispensable
element
life,
phosphorus
chemistry
now
experiencing
renaissance
due
new
emerging
applications
in
medicinal
chemistry,
materials
(polymers,
flame
retardants,
organic
electronics,
photonics),
agricultural
(herbicides,
insecticides),
catalysis
(ligands)
other
important
areas
science
technology.
In
this
regard,
search
for
new,
more
selective,
low-waste
routes
become
relevant.
context,
electrosynthesis
has
proven
be
eco-efficient
convenient
approach
many
respects,
where
reagents
are
replaced
by
electrodes,
reactants
applied
potential
determines
their
“oxidizing
or
reducing
ability”.
An
electrochemical
such
processes
being
developed
rapidly
demonstrates
some
advantages
over
traditional
classical
methods
C-H
phosphorylation.
main
reasons
success
exclusion
excess
from
reaction
system:
as
oxidants,
agents,
sometimes
metal
and/or
improvers,
challenge
isolation,
increase
wastes
reduce
yield
frequent
incompatibility
with
these
Ideal
conditions
include
electron
reactant
(regulated
potential)
by-products
hydrogen
hydrocarbon.
review
summarizes
analyzes
achievements
preparation
various
derivatives
carbon-phosphorus
bonds,
collects
data
redox
properties
most
commonly
used
precursors.
Electrochemically
induced
reactions
both
without
catalyst
metals,
competitive
oxidation
precursors
leads
either
bond
generation
phosphorus-centered
radicals
(radical
cations)
states
will
examined.
focuses
publications
past
5
years.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(14), P. 5721 - 5726
Published: Jan. 1, 2023
Herein,
metal-free
phosphonation
of
N-heterocycles
with
diphenylphosphine
oxides,
promoted
by
1,5-diazabicyclo[5,4,0]undec-5-ene
utilizing
air
as
a
green
oxidant
in
dimethyl
carbonate
an
eco-friendly
solvent
at
room
temperature,
is
presented.
The Chemical Record,
Journal Year:
2020,
Volume and Issue:
20(12), P. 1530 - 1552
Published: Oct. 5, 2020
Abstract
Organophosphorus
chemistry
is
a
broad
field
with
multi‐dimensional
applications
in
research
area
of
organic,
biology,
drug
design
and
agrochemicals.
Conventional
methods
have
been
adopted
extensively
to
access
phosphorylated
compounds
that
rely
on
the
use
toxic,
moisture
sensitive
phosphorylating
agents
occur
presence
oxidants,
catalysts,
as
well
high
temperatures
harsh
conditions
are
required
for
complete
transformations.
However,
recent
progress
has
made
phosphorylation
reactions
using
electricity
introduce
green
sustainable
synthetic
procedures.
These
can
be
performed
at
mild
proceed
excellent
atom
economy.
Herein,
we
targeted
electrochemical
generation
new
bonds
such
C(sp
3
)
−P,
2
O−P,
N−P,
S−P
Se−P.
This
review
aimed
offer
an
overview
developments
methodology
easy
organophosphorus
electrochemistry.
