Copper(I)-Catalyzed Asymmetric Nucleophilic Addition to Aldehydes with Skipped Enynes DOI
Cheng Peng, Tianle Wu, Xueyan Yang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(47), P. 10072 - 10077

Published: Nov. 18, 2024

The development of sustainable and novel strategies for constructing complex chiral molecules with versatile transformation potential is a long-term pursuit in the chemistry community. We report copper(I)-catalyzed enyne addition to aldehydes under proton-transfer conditions, unlike previous examples which were limited use preformed reactive nucleophiles containing allylic heteroatoms or electron-withdrawing groups. This protocol provides an efficient platform installing alcohol moieties broad substrate scope high regio-, stereo-, enantioselectivity.

Language: Английский

Photoexcited Hantzsch Ester and Cobalt Catalysis Enable Diastereo- and Enantioselective Allylation of Aldehydes DOI

Junjie Xue,

Jiaming Zou,

Shen Gao

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 6165 - 6172

Published: April 2, 2025

Language: Английский

Citations

0
Copper(I)-Catalyzed Asymmetric Nucleophilic Addition to Aldehydes with Skipped Enynes DOI
Cheng Peng, Tianle Wu, Xueyan Yang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(47), P. 10072 - 10077

Published: Nov. 18, 2024

The development of sustainable and novel strategies for constructing complex chiral molecules with versatile transformation potential is a long-term pursuit in the chemistry community. We report copper(I)-catalyzed enyne addition to aldehydes under proton-transfer conditions, unlike previous examples which were limited use preformed reactive nucleophiles containing allylic heteroatoms or electron-withdrawing groups. This protocol provides an efficient platform installing alcohol moieties broad substrate scope high regio-, stereo-, enantioselectivity.

Language: Английский

Citations

0