Electrochemical Heteroarylation and Amidation of Alkanes using Activated Glassy Carbon Electrodes without Mediators DOI
Irene Bosque, José C. González‐Gómez,

Loris Laze

et al.

Published: Oct. 23, 2024

Abstract The functionalization of challenging unactivated C(sp3)-H bonds was achieved electrocatalytically via hydrogen atom transfer and without mediators. This possible through the sole activation surface Glassy Carbon Electrode in an electrochemical fashion using a phosphate buffer. produced oxygenated functional groups on surface, capable abstracting these atoms from alkanes. Minisci Ritter-type reactions were this procedure. Extensive characterization AGCE preliminary mechanistic studies allow us to propose plausible reaction mechanisms. Furthermore, regular battery can be used within protocol achieve desired substituted alkanes under inexpensive user-friendly conditions.

Language: Английский

Electrochemical heteroarylation and amidation of alkanes using activated glassy carbon electrodes without mediators DOI Creative Commons

Loris Laze,

José C. González‐Gómez, Irene Bosque

et al.

Communications Chemistry, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 29, 2025

The functionalization of challenging unactivated C(sp3)–H bonds was achieved electrocatalytically via hydrogen atom transfer and without mediators. This possible through the sole activation surface Glassy Carbon Electrode (GCE) in an electrochemical fashion using a phosphate buffer. produced oxygenated functional groups on surface, capable abstracting these atoms from alkanes. Minisci Ritter-type reactions were this procedure. Extensive characterization activated GCE (AGCE) preliminary mechanistic studies allow us to propose plausible reaction mechanisms. Furthermore, regular battery can be used within protocol achieve desired substituted alkanes under inexpensive user-friendly conditions. Aliphatic compounds play crucial role pharmaceutical agrochemical industries, however, selective modification structures remains due high strength bonds. Here, authors report Minisci-type alkylation azaarenes with Ritter between nitriles glassy carbon electrode, achieving electrocatalytic inert that eliminates need for traditional mediators or metals.

Language: Английский

Citations

0
Electrophotocatalytic Hydroxymethylation of Azaarenes with Methanol DOI Creative Commons

Beatriz Quevedo-Flores,

Irene Bosque, José C. González‐Gómez

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(35), P. 7447 - 7451

Published: Aug. 24, 2024

The merging of electrochemistry and photocatalysis allowed the required selectivity for hydroxymethylation functionalized azaarenes with methanol, including bioactive substrates. two electrophotocatalytic protocols developed in this work address transformation, using nontoxic readily available reagents under mild reaction conditions electricity as only "sacrificial oxidant".

Language: Английский

Citations

3
Electrochemical Heteroarylation and Amidation of Alkanes using Activated Glassy Carbon Electrodes without Mediators DOI
Irene Bosque, José C. González‐Gómez,

Loris Laze

et al.

Published: Oct. 23, 2024

Abstract The functionalization of challenging unactivated C(sp3)-H bonds was achieved electrocatalytically via hydrogen atom transfer and without mediators. This possible through the sole activation surface Glassy Carbon Electrode in an electrochemical fashion using a phosphate buffer. produced oxygenated functional groups on surface, capable abstracting these atoms from alkanes. Minisci Ritter-type reactions were this procedure. Extensive characterization AGCE preliminary mechanistic studies allow us to propose plausible reaction mechanisms. Furthermore, regular battery can be used within protocol achieve desired substituted alkanes under inexpensive user-friendly conditions.

Language: Английский

Citations

0