The association between long-term exposure to PM2.5 constituents and ischemic stroke in the New York City metropolitan area

Chemosphere, Journal Year: 2025, Volume and Issue: 378, P. 144390 - 144390

Published: April 8, 2025

Numerous studies linked fine particulate matter (PM2.5) to ischemic stroke. However, only a few investigated the differential associations with specific PM2.5 components and sources. We utilized electronic health records (EHR) from Mount Sinai Health System in New York City metropolitan area during 2011-2019 assessed of sources used mixed-effect Poisson survival regressions assess single-exposure chemical components. multivariable regression simultaneous source-apportioned exposures estimated using non-negative matrix factorization. Then, we sensitivity our results different specifications EHR data continuity: (1) less strict definition censorship year, (2) adjusting model for continuity index, validated algorithm measuring EHR-data based on indicators primary care service utilization. observed higher risks stroke (Risk ratio [95 % confidence intervals] per interquartile range increase) associated exposure nickel (1.080 [1.045; 1.116]), vanadium (1.070 [1.033; 1.109]), zinc (1.076 [1.031; 1.122]), nitrate (1.084 [1.039; 1.132]). In multivariate models found risk oil combustion sourced (1.061 [1.012; 1.113]). The remained consistent under accounting continuity. conclusion, an increased These findings were robust Our can inform policy interventions aimed at reducing cardiovascular disease burden.

Language: Английский

Atherosclerotic Cardiovascular Disease Mortality and PM _2.5 Air Pollution — Role of Pollution Sources?

NEJM Evidence, Journal Year: 2024, Volume and Issue: 3(12)

Published: Nov. 26, 2024

By the mid-1990s, there was compelling epidemiologic evidence that exposure to particulate matter air pollution contributes respiratory disease. Daily elevations in were associated with reduced lung function, increased symptoms of illness, hospital admissions, and an daily mortality rate. Surprisingly, also acute ischemic heart disease events, strokes, cardiovascular hospitalizations deaths. Prospective cohort studies provided further long-term fine-particulate-matter pollution, is, pollutants a mass median aerodynamic diameter 2.5 μm or less (PM2.5), both mortality.1

Language: Английский