Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 17, 2023
Abstract
Chronic
kidney
disease
(CKD)
is
estimated
to
affect
10–14%
of
global
population.
Kidney
fibrosis,
characterized
by
excessive
extracellular
matrix
deposition
leading
scarring,
a
hallmark
manifestation
in
different
progressive
CKD;
However,
at
present
no
antifibrotic
therapies
against
CKD
exist.
fibrosis
identified
tubule
atrophy,
interstitial
chronic
inflammation
and
fibrogenesis,
glomerulosclerosis,
vascular
rarefaction.
Fibrotic
niche,
where
organ
initiates,
complex
interplay
between
injured
parenchyma
(like
tubular
cells)
multiple
non-parenchymal
cell
lineages
(immune
mesenchymal
located
spatially
within
scarring
areas.
Although
the
mechanisms
are
complicated
due
kinds
cells
involved,
with
help
single-cell
technology,
many
key
questions
have
been
explored,
such
as
what
kind
renal
tubules
profibrotic,
myofibroblasts
originate,
which
immune
how
communicate
each
other.
In
addition,
genetics
epigenetics
deeper
that
regulate
fibrosis.
And
reversible
nature
epigenetic
changes
including
DNA
methylation,
RNA
interference,
chromatin
remodeling,
gives
an
opportunity
stop
or
reverse
therapeutic
strategies.
More
marketed
(e.g.,
RAS
blockage,
SGLT2
inhibitors)
developed
delay
progression
recent
years.
Furthermore,
better
understanding
also
favored
discover
biomarkers
fibrotic
injury.
review,
we
update
advances
mechanism
summarize
novel
treatment
for
CKD.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(3), P. 636 - 636
Published: Feb. 1, 2019
The
perspectives
of
regenerative
medicine
are
still
severely
hampered
by
the
host
response
to
biomaterial
implantation,
despite
robustness
technologies
that
hold
promise
recover
functionality
damaged
organs
and
tissues.
In
this
scenario,
cellular
molecular
events
decide
on
implant
success
tissue
regeneration
played
at
interface
between
foreign
body
inflammation,
determined
innate
adaptive
immune
responses.
To
avoid
adverse
events,
rather
than
use
inert
scaffolds,
current
state
art
points
immunomodulatory
biomaterials
their
knowledge-based
reduce
neutrophil
activation,
optimize
M1
M2
macrophage
polarization,
Th1
Th2
lymphocyte
switch,
Treg
induction.
Despite
fact
field
is
evolving
much
remains
be
accomplished,
recent
research
breakthroughs
have
provided
a
broader
insight
correct
choice
physicochemical
modifications
tune
reaction
system
implanted
favor
integration
healing.
Journal of Clinical Investigation,
Journal Year:
2018,
Volume and Issue:
128(1), P. 45 - 53
Published: Jan. 1, 2018
The
extracellular
matrix
(ECM)
is
dynamically
tuned
to
optimize
physiological
function.
Its
major
properties,
including
composition
and
mechanics,
profoundly
influence
cell
biology.
Cell-ECM
interactions
operate
through
an
integrated
set
of
sensor
effector
circuits
that
use
several
classes
receptors
signal
transduction
pathways.
At
the
single-cell
level,
ECM
governs
differentiation,
metabolism,
motility,
orientation,
proliferation,
survival.
population
provides
higher-order
guidance
essential
for
When
pathological
changes
in
lead
impairment
organ
function,
we
term
“fibrosis.”
In
this
Review,
differentiate
fibrosis
initiation
from
progression
focus
primarily
on
progressive
lung
impairing
We
present
a
working
model
explain
how
altered
not
only
consequence
but
also
driver
fibrosis.
Additionally,
advance
concept
occurs
fibrogenic
niche
composed
nurtures
mesenchymal
progenitor
cells
their
progeny.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Aug. 7, 2020
Abstract
Many
important
cell
types
in
adult
vertebrates
have
a
mesenchymal
origin,
including
fibroblasts
and
vascular
mural
cells.
Although
their
biological
importance
is
undisputed,
the
level
of
heterogeneity
within
between
organs,
while
appreciated,
has
not
been
analyzed
detail.
Here,
we
compare
single-cell
transcriptional
profiles
cells
across
four
murine
muscular
organs:
heart,
skeletal
muscle,
intestine
bladder.
We
reveal
gene
expression
signatures
that
demarcate
from
provide
molecular
for
subtype
identification.
observe
striking
inter-
intra-organ
amongst
fibroblasts,
primarily
reflecting
differences
extracellular
matrix
components.
Fibroblast
subtypes
localize
to
discrete
anatomical
positions
offering
novel
predictions
about
physiological
function(s)
regulatory
signaling
circuits.
Our
data
shed
new
light
on
diversity
poorly
defined
classes
foundation
improved
understanding
roles
pathological
processes.
