Cited by Snakebites in the Americas: a Neglected Problem in Public Health

Clinical aspects of snakebite envenoming and its treatment in low-resource settings DOI

David A. Warrell, David J. Williams

The Lancet, Journal Year: 2023, Volume and Issue: 401(10385), P. 1382 - 1398

Published: March 14, 2023

Language: Английский

Citations

Effects of heparin on venom-induced consumption coagulopathy: a meta-analysis of randomized controlled trials DOI

Yuning Huang, Wei‐Chuan Chang, Yun-Kuan Lin

et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Venom-induced consumption coagulopathy (VICC) is a serious complication of snakebites, potentially leading to life-threatening bleeding. Despite efforts determine effective treatments other than antivenom, such as heparin, the evidence supporting their use remains insufficient. Therefore, this study aimed perform systematic review, meta-analysis and trial sequential analysis (TSA) examine effects heparin on VICC. On 11 August 2024, search for randomized controlled trials (RCTs) investigating VICC was conducted using eight online databases. Six RCTs were included in study. The revealed that did not significantly reduce mortality rate (risk ratio, 0.65; 95% CI 0.39 1.10). Additionally, showed no significant differences various clinical outcomes between group control group. TSA indicated insufficient conclude mortality, sample size 741 patients may be needed further RCTs. In conclusion, our findings indicate affect outcomes. Although current inconclusive because limited size, it highlights need future provide more precise insights.

Language: Английский

Citations

Characteristics of snakebite patients due to Naja samarensis in the Philippines: a prospective hospital-based study DOI

Yoshihiro Aoki,

Jonathan Paghubasan,

Patrick Joseph Tiglao

et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Background Little is known about snakebites by Naja samarensis, a species unique to the Philippines. The aim here describe clinical and epidemiological characteristics of patients bitten this medically important cobra in Eastern Visayas. Methods A hospital-based prospective study analysed features snakebite attending Visayas Medical Center between June 2022 May 2023. Logistic regression analysis identified factors associated with severity. Results total 175 five fatalities were included. samarensis was most commonly implicated (n=49, 28.0%), although it could be definitively identified, examining photographs snake responsible, only four cases. N. bites occurred grass or rice fields, daytime, during farming activities, but people frequently students (34.7%) who at home (36.7%). Patients often presented cytotoxic (63.3%) neurotoxic signs (46.9%). Traditional remedies common, resulting delayed presentation hospital. Bites older age (>44 y) independently severity (adjusted OR 10.33 7.89, respectively). Conclusion major cause severe region. Pre-hospital treatment involves wasted time unproven traditional methods. Enhancement public awareness urgently needed. Development diagnostic test for identification warranted improve future surveys management.

Language: Английский

Citations

Medically important snakes in Sudan: an overview of distribution, clinical features and present challenges DOI

Rania M. H. Baleela, Muhammad E. M. O. Elamin, Abubakr Mohammad

et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Snakebite envenomation (SBE) is a neglected tropical disease. It causes substantial morbidity and mortality in Sudan. Despite its endemicity, there lack of up-to-date data on venomous snakes their geographical distribution Sudan, with most information dating back to the early twentieth century. To address this gap, we conducted narrative review literature SBE This involved systematic searches databases, historical publications online resources from 1908 2024. Integrating findings personal field experiences provide comprehensive overview situation identified 19 medically significant snake species Sudan four families. These exhibit range venom types clinical effects, including neurotoxic, hemotoxic cytotoxic envenomation. The dangerous important are carpet viper (Echis pyramidum), Nubian cobra (Naja nubiae) burrowing asp (Atractaspis phillipsi). Challenges snakebite management include non-availability specific antivenoms, inadequate healthcare infrastructure reliance traditional medicine. We recommend establishing national registry, improving infrastructure, developing training programs for professionals increasing public awareness. Strengthening international collaborations antivenom production investing molecular research also crucial reducing severity associated

Language: Английский

Citations

Community-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda DOI

Dileepa Senajith Ediriweera, Dieudonne Hakizimana, Peter J. Diggle

et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Background Snakebite envenoming is a medical emergency that requires rapid access to essential medicines and well-trained personnel. In resource-poor countries, mapping snakebite incidence can help policymakers make evidence-based decisions for resource prioritisation. This study aimed characterise the spatial variation in risk, particular identify areas of relatively high low Eastern Province, Rwanda. Methods surveillance people bitten 2020 was conducted Province through household visits case verification. Geostatistical modelling predictive were applied data from 617 villages six districts develop sector-level district-level risk maps. Results There 1217 individuals by snakes across districts. The estimated population-weighted 440 (95% interval 421 460) cases per 100 000 people, corresponding 13 500 12 950 14 150) events year. Two sectors southwest, Gashanda Jarama, showed >1500 annually. lowest observed north. Conclusions Considerable differences exist between with highest concentrated southwest. Policymakers should consider prioritising resources related prevention, health worker training this region.

Language: Английский

Citations

Impact of Patient-Centered Care on Treatment Outcomes of Multidrug-Resistant/Rifampicin-Resistant Tuberculosis in Xi’an DOI

Hui Luo,

Jin-Bao Ma, Xiao Shun He

et al.

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 1425 - 1437

Published: March 1, 2025

A hospital in Xi'an, Shaanxi Province, China, implemented patient-centered care services to improve the treatment outcomes of patients with multidrug-resistant/rifampicin-resistant tuberculosis. Given high recurrence rate and challenges this disease, study aimed evaluate effects compared standard improving patient adherence reducing loss follow-up. This single-center retrospective cohort included tuberculosis diagnosed treated at Xi'an Tuberculosis Prevention Treatment Hospital from January 2018 December 2019. Descriptive statistics, survival analysis, multivariate Cox regression analysis were used analyze impact on adherence. Data collection patients' demographic characteristics, clinical data, outcomes, reasons for total 429 final 166 standard-of-care group 263 group. The success (86.3%) was significantly higher than (59.0%), follow-up lower (6.8% vs 30.1%). Multivariate showed that reduced risk (adjusted odds ratio 0.14). main economic difficulties, lack knowledge, inadequate social support. model improved patients, demonstrating potential benefits managing drug-resistant Based these findings, exploring optimizing other high-burden areas is recommended enhance overall quality life patients.

Language: Английский

Citations

Disseminated Intravascular Coagulation: The Past, Present, and Future Considerations DOI

Toshiaki Iba, Marcel Levi, Jecko Thachil

et al.

Seminars in Thrombosis and Hemostasis, Journal Year: 2022, Volume and Issue: 48(08), P. 978 - 987

Published: Sept. 13, 2022

Abstract Disseminated intravascular coagulation (DIC) has been understood as a consumptive coagulopathy. However, impaired hemostasis is component of DIC that occurs in progressive manner. The critical concept systemic activation with vascular endothelial damage. the dynamic coagulation/fibrinolysis disorder can proceed from compensated to decompensated phases, and not simply hemostasis, misunderstanding continues evoke confusion among clinicians. step disease progression important monitor over time. Impaired microcirculation subsequent organ failure due pathologic microthrombi formation are pathophysiologies sepsis-associated DIC. factor depletion hemodilution, shock, hyperfibrinolysis trauma-associated Overt-DIC diagnostic criteria have used clinically for more than 20 years but may be adequate detect phase DIC, different underlying causes, there no “one-size-fits-all criteria.” Individualized heterogeneous conditions continue proposed facilitate diagnosis. We believe future research will provide therapeutics using new criteria. Finally, also classified either acute or chronic, results short time requires urgent management. In this review, we examine advances

Language: Английский

Citations

Inflammation and Oxidative Stress in Snakebite Envenomation: A Brief Descriptive Review and Clinical Implications DOI

Dabor Résière, Hossein Mehdaoui, Rémi Névière

et al.

Toxins, Journal Year: 2022, Volume and Issue: 14(11), P. 802 - 802

Published: Nov. 18, 2022

Snakebite envenoming is a pathological condition which may occur in response to the injection of venom. Snake venoms contain complex mixture biologically active molecules are responsible for broad spectrum clinical manifestations, ranging from local tissue injuries fatal complications. venom administration commonly provokes injury often associated with systemic effects, including neurotoxic and cardiotoxic bleeding, acute kidney injury, rhabdomyolysis. An important pathogenesis snake envenomation generation reactive oxygen species (ROS), can directly provoke damage also potentiate deleterious consequences inflammation at bite site. components known induce oxidative stress include phospholipases A2, metalloproteinases, three-finger toxins, L-amino acid oxidase. Clear evidence mounting suggesting that participate destructive effects envenoming, renal failure, necrosis, unusual susceptibility bleed (hemorrhage), mostly due hypocoagulability, neuro/cardio toxicity, myonecrosis. Impaired regulation set stage secondary/long-term complications snakebite such as musculoskeletal disabilities. Some aspects natural antioxidant therapeutic options discussed this review.

Language: Английский

Citations

Antibodies as Snakebite Antivenoms: Past and Future DOI

Wilmar Dias da Silva, Sonia Aparecida de Andrade, Ângela Alice Amadeu Megale

et al.

Toxins, Journal Year: 2022, Volume and Issue: 14(9), P. 606 - 606

Published: Sept. 1, 2022

Snakebite envenomation is considered a neglected tropical disease, affecting tens of thousands people each year. The recommended treatment the use antivenom, which composed immunoglobulins or immunoglobulin fragments obtained from plasma animals hyperimmunized with one (monospecific) several (polyspecific) venoms. In this review, efforts made in improvement already available antivenoms and development new antivenoms, focusing on snakes medical importance sub-Saharan Africa Latin America, are described. Some currently used whole IgGs, whereas others F(ab’)2 fragments. classic methods attaining snake presented, addition to strategies improve their effectiveness. Punctual changes immunization protocols, cross-reactivity between venoms different for manufacture more potent widely presented. It known that complex mixture components; however, advances field have shown there key toxins that, if effectively blocked, capable reversing condition vivo envenomation. These studies provide an opportunity monoclonal antibodies new-generation antivenoms. Thus, described as possible alternative production regardless venom. This review also highlights challenges associated development.

Language: Английский

Citations

Snakebite-Associated Infections: A Systematic Review and Meta-Analysis DOI

D. Katterine Bonilla‐Aldana, Jorge Luis Bonilla-Aldana, Juan R. Ulloque‐Badaracco

et al.

American Journal of Tropical Medicine and Hygiene, Journal Year: 2024, Volume and Issue: 110(5), P. 874 - 886

Published: May 1, 2024

ABSTRACT. Snakebites still constitute a significant public health problem in developing countries and are considered neglected tropical condition by the WHO. Snake accidents associated with substantial morbidity mortality may produce secondary complications, such as severe infections. The objective of this systematic review was to determine prevalence snakebite infections characterize bacteria isolated from these A literature five databases carried out assess infection. meta-analysis performed using random-effects model calculate pooled 95% CIs. Cochran’s Q test I 2 statistic were used between-study heterogeneity. infection due 27.0% (95% CI: 22.0–32.0%), high heterogeneity among studies ( = 99.7%). higher Asia (32%) than Americas (21%). Snakebite required surgical interventions 68% 37.0–98.0%). leading group pathogens identified corresponded Gram-negative (63%), particularly Morganella morganii (32%), but also, Gram-positive cocci (40%), especially Enterococcus spp. (23%) Staphylococcus aureus (15%). However, multiple other pathogens, including anaerobes, found. snakebite-associated has been described, primarily M. , corresponding implications for empirical therapy. Rational use antimicrobials is recommended, should guide initial treatment. Moreover, isolation identification possible present wounds recommended all cases confirm or rule

Language: Английский

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