Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis DOI Creative Commons
Shmuel Shoham, Sabin Thapaliya, Robin K. Avery

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Background Meningitis due to Cryptococcus neoformans continues cause substantial morbidity and mortality in victims of this infection. Worldwide, immunosuppression uncontrolled HIV disease is the main risk factor. In United States, however, a percentage cryptococcal meningitis cases occur people with non-HIV immune compromising conditions such as solid organ transplantation. Neurological damage can be caused by direct fungal-induced injury, consequence elevated intracranial pressure, immune-mediated injury. An understanding these pathophysiological processes an appreciation for roles specific treatments address them are necessary optimal care patients meningitis. Case Summary report, we present case liver transplant recipient whose manifestations were (i) fungal invasion, (ii) (iii) over-exuberant response that blossomed soon after reduction clearance cerebrospinal fluid culture. Conclusion This patient’s course exemplifies multidimensional nature neurological injury diverse treatment strategies required infection complications. IMPORTANCE critical management highlights three so they quickly diagnosed treated before irreversible occurs.

Language: Английский

Case report: A diabetic patient with cryptococcal meningoencephalitis complicated by post-infectious inflammatory response syndrome DOI Creative Commons
Qinghua Chen, Wei Yu, Xuyi Wang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 27, 2024

We report on a previously non-HIV-diagnosed, 47-year-old male diagnosed with diabetes mellitus (DM) and cryptococcal meningoencephalitis, who was referred to our institution for antifungal treatment. During the course of treatment, due development refractory intracranial hypertension, Ommaya reservoirs were employed cranial pressure reduction. The patient gradually recovered during subsequent therapy; however, symptoms worsened in third month leading consideration post-infectious inflammatory response syndrome (PIIRS) examination. Once diagnosed, improved significantly after approximately 130 days treatment additional corticosteroids.

Language: Английский

Citations

0
Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis DOI Creative Commons
Shmuel Shoham, Sabin Thapaliya, Robin K. Avery

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Background Meningitis due to Cryptococcus neoformans continues cause substantial morbidity and mortality in victims of this infection. Worldwide, immunosuppression uncontrolled HIV disease is the main risk factor. In United States, however, a percentage cryptococcal meningitis cases occur people with non-HIV immune compromising conditions such as solid organ transplantation. Neurological damage can be caused by direct fungal-induced injury, consequence elevated intracranial pressure, immune-mediated injury. An understanding these pathophysiological processes an appreciation for roles specific treatments address them are necessary optimal care patients meningitis. Case Summary report, we present case liver transplant recipient whose manifestations were (i) fungal invasion, (ii) (iii) over-exuberant response that blossomed soon after reduction clearance cerebrospinal fluid culture. Conclusion This patient’s course exemplifies multidimensional nature neurological injury diverse treatment strategies required infection complications. IMPORTANCE critical management highlights three so they quickly diagnosed treated before irreversible occurs.

Language: Английский

Citations

0