APL Bioengineering, Journal Year: 2023, Volume and Issue: 7(4)
Published: Oct. 9, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13043 - 13043
Published: Aug. 22, 2023
The use of platelet-rich plasma (PRP) has gained increasing interest in recent decades. platelet secretome contains a multitude growth factors, cytokines, chemokines, and other biological biomolecules. In years, developments the field platelets have led to new insights, attention been focused on platelets’ released extracellular vesicles (EVs) their role intercellular communication. this context, aim review was compile current evidence PRP-derived identify advantages limitations fortheir upcoming clinical applications. A total 172 articles were identified during systematic literature search through two databases (PubMed Web Science). Twenty publications met inclusion criteria included review. According results, PRP-EVs clinic is an emerging great that represents promising therapeutic option, as efficacy demonstrated majority fields applications However, lack standardization along procedures both PRP EVs makes it extremely challenging compare results among studies. Establishing standardized conditions ensure optimized detailed protocols define parameters such dose or EV origin therefore urgent. Further studies elucidate real contribution terms composition functionality should also be performed. Nevertheless, research provides novel basis deal with regenerative medicine drug delivery future.
Language: Английский
Citations
30
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 16 - 16
Published: Jan. 9, 2025
This review aims to explore the clinical applications, biological mechanisms, and potential benefits of concentrated growth factors (CGFs), autologous materials, xenografts in bone regeneration, particularly dental treatments such as alveolar ridge preservation, mandibular osteonecrosis, peri-implantitis. A systematic literature search was conducted using databases like PubMed, Scopus, Web Science, with keywords "bone regeneration" "CGF" from 2014 2024. Only English-language studies involving human subjects were included. total 10 selected for qualitative analysis. Data processed through multiple stages, including title abstract screening full-text evaluation. The findings reviewed underscore CGF enhancing regeneration stimulating cell proliferation, angiogenesis, extracellular matrix mineralization. Autologous materials have also demonstrated promising results due their biocompatibility capacity seamless integration natural tissue. When combined xenografts, these show synergistic effects improving quantity quality, which are crucial implant success. Future research should focus on direct comparisons different techniques, optimization protocols, broader applications beyond medicine. CGFs into routine practice represents a significant advancement regenerative medicine, improved patient outcomes satisfaction.
Language: Английский
Citations
1
BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 28, 2025
Language: Английский
Citations
1
Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: April 25, 2025
Platelets, long recognized for their role in hemostasis and thrombosis, have emerged as key players a wide array of physiological pathological processes through the release platelet-derived extracellular vesicles (PEVs). These nanoscale vesicles, rich bioactive molecules such proteins, lipids, nucleic acids, facilitate intercellular communication influence ranging from angiogenesis inflammation to immune modulation tissue repair. PEVs, most abundant circulation, display procoagulant activity 50-100 times greater than activated platelets, underscoring pivotal thrombosis. Recent research has unveiled dual health disease, highlighting potential diagnostic biomarkers therapeutic vehicles. PEVs are implicated cancer progression, autoimmune diseases, infectious where they modulate tumor microenvironments, responses, inflammatory pathways. Moreover, ability deliver agents with high specificity biocompatibility positions them promising tools regenerative medicine, drug delivery, targeted therapies. This review comprehensively explores PEV biogenesis, cargo composition, multifaceted roles well broader implications disease. It also markers innovative strategies, offering insights into application treating thrombotic disorders, cancer, diseases. Despite significant advancements, challenges remain standardizing isolation protocols translating preclinical findings clinical applications. Unlocking full promises revolutionize diagnostics therapeutics, paving way novel approaches managing complex
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(10), P. 2189 - 2189
Published: Oct. 14, 2022
Introduction: this study was conducted to investigate the osteogenic ability of periodontal ligament stem cells (PDLSCs) derived exosomes (PDLSCs-Exos) and effect PDLSCs-Exos with hydrogel on alveolar bone defect repairment in rat. Methods: PDLSCs were obtained through primary cell culture, purified by ultracentrifugation method. The CCK-8 kit ALP staining used explore promoting proliferation differentiation marrow mesenchymal (BMSCs). In vivo, models made mesial bilateral maxillary first molars rats. MicroCT, HE staining, Masson analyze new at Results: successfully extracted. results showed significantly promoted BMSCs. vivo experiment revealed that compared control group group, rats more formation defects. Conclusion: Periodontal from demonstrated delivered for repairing defects initial stage.
Language: Английский
Citations
39
Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(6), P. 290 - 290
Published: May 24, 2023
Bioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and substantially improved translational clinical applications. However, their limitations side effects still need to be explored elucidated. This article aims review the recent advancements discuss future research directions this field, especially focusing on using improve health. The biomimetic physiochemical properties of such as metals polymer composites described detail, including alveolar bone, ligament, cementum gingiva. Finally, biomedical safety issues application regenerative materials updated, with a discussion about complications perspectives. Although applications bioactive cavity at an initial stage, pose numerous challenges, suggests that promising alternative regeneration.
Language: Английский
Citations
17
Tissue Engineering Part B Reviews, Journal Year: 2023, Volume and Issue: 29(5), P. 532 - 544
Published: April 8, 2023
Guided tissue regeneration (GTR) is an important surgical method for periodontal regeneration. By placing barrier membrane on the root surface of tooth to guide adhesion and proliferation ligament cells, can be achieved. This review intends analyze current limitations GTR membranes propose possible solutions developing new ones. Limitations include nonabsorbable absorbable synthetic polymer exhibit weak biocompatibility; when applying a large defect wound, natural collagen with fast degradation rate have limited mechanical strength, function may not maintained well. Although time prolonged after cross-linking, it cause foreign body reaction affect integration; The clinical operation inconvenient. In addition, most lack bioactivity will actively promote Possible using electrospinning (ELS) techniques, nanofiber scaffolds, or functional gradient improve their adding Mg, Zn, and/or other metal alloys, 3D printing technology strength; increasing concentration nanoparticles directional arrangement fibers control fiber diameter porosity membrane, which function; mixing polymers as well biomaterials different rates in proportion change maintain convenience operation, that meets personalized wound manufactured; local controlled release drug delivery systems bioactivity. Impact statement provides up-to-date summary commonly commercial guided membranes, use. Using studies published recently explore from several perspectives raise strategies future. Several tested vivo/in vitro, way propel translation, meeting needs.
Language: Английский
Citations
13
Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(4)
Published: April 1, 2024
Language: Английский
Citations
4
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2844 - 2844
Published: April 20, 2025
Introduction: The physiological process of wound healing is a complex and dynamic series events that aims to restore damaged tissues their original structure function. Platelet-rich plasma (PRP), an autologous blood-derived product, characterized by high concentration platelets suspended in small volume plasma, along with complete array coagulation factors at concentrations. Beyond platelets, PRP contains significant quantity bioactive growth factors, such as platelet-derived factor (PDGF), vascular endothelial (VEGF), transforming factor-beta (TGF-β), all which are crucial mediators tissue repair osteogenesis. Due these properties, has garnered considerable attention oral surgery, where the efficient regeneration both hard soft critical for optimal therapeutic outcomes. Objectives: This systematic review aimed critically evaluate efficacy surgical procedures, particular emphasis on its role tissues, well clinical Furthermore, sought identify diverse applications assess impact use conjunction grafting materials regenerative Methods: A comprehensive was conducted, analyzing articles published within last decade regarding application specifically focusing periodontal, regenerative, implant-related procedures. Studies were selected based rigorous inclusion criteria, assessing utilization across different settings. Results: Fourteen relevant studies included, categorized follows: four involving implant three third molar extractions, two addressing periodontal one study examining intrabony defects, ridge augmentation majority reported modest improvements parameters probing depth attachment level (CAL). positive outcomes observed healing, notable enhancements bone density. These results suggest may facilitate process, particularly while also promoting degree. Conclusions: findings this underscore potential valuable adjunct demonstrating benefits and, lesser extent, tissues. Notably, standalone did not yield substantial However, when used combination materials, more pronounced observed, indicating synergistic effect enhances regeneration. support rationale incorporating into practice, optimize patient surgery. Further research, larger sample sizes long-term follow-ups, necessary fully elucidate mechanistic pathways
Language: Английский
Citations
0
Platelets, Journal Year: 2024, Volume and Issue: 35(1)
Published: Sept. 17, 2024
Platelet-derived extracellular vesicles (PEVs) are released by platelets in the blood circulation, which carry a rich bio-molecular cargo influential intercellular communications. PEVs can enter lymph, bone marrow, and synovial fluid as nano-sized particles, while cannot cross tissue barriers. Considering advantages of such low immunogenicity, high regulation signal transduction, easy obtainment, may be promising therapeutic tools for medical applications. The exceptional functional roles played explain recent interest exploring new cell-free therapies that could address needs angiogenesis, regenerative medicine, targeted drug delivery. review takes critical look at main advances treatment diseases presenting latest knowledge from performed studies, order to enhance further translation research into feasible
Language: Английский
Citations
3