Inkjet-printed transparent electrodes: Design, characterization, and initial in vivo evaluation for brain stimulation

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320376 - e0320376

Published: April 1, 2025

Electrical stimulation is a powerful tool for investigating and modulating brain activity, as well treating neurological disorders. However, understanding the precise effects of electrical on neural activity has been hindered by limitations in recording neuronal responses near stimulating electrode, such artifacts electrophysiology or obstruction field view imaging. In this study, we introduce novel device fabricated from conductive polymers that transparent therefore compatible with optical imaging techniques. The manufactured using combination microfabrication inkjet printing techniques flexible, allowing better adherence to brain’s natural curvature. We characterized properties electrodes, focusing trade-off between maximum current can be delivered transmittance. found 1 mm diameter, 350 nm thick PEDOT:PSS electrode could used apply 130 μA while maintaining 84% transmittance (approximately 50% under 2-photon conditions). then evaluated performance an anesthetized mouse measuring electric nearby values up 30 V/m. Finally, combined experimental data finite-element model vivo setup estimate distribution underneath brain. Our findings indicate generate high 300 V/m directly beneath demonstrating its potential studying manipulating range relevant human applications. Overall, work presents promising approach developing versatile new tools study stimulation.

Language: Английский

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Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(20)

Published: Dec. 13, 2023

Abstract The field of bioelectronics with the aim to contact cells, cell clusters, biological tissues and organoids has become a vast enterprise. Currently, it is mainly relying on classical micro‐ nanofabrication methods build devices systems. Very recently highly pushed by development novel printable organic, inorganic biomaterials as well advanced digital printing technologies such laser inkjet employed in this endeavor. Recent advantages alternative additive manufacturing 3D enable interesting new routes, particular for applications requiring incorporation delicate or creation scaffold structures that show high potential building hybrid bio‐/inorganic devices. Here current state printed 2D electronic related lithography techniques interfacing systems are reviewed. focus lies vitro single cell, organoids. Challenges future prospects discussed all‐printed bio/electronic targeting biomedical research, diagnostics, health monitoring.

Language: Английский

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Emerging technologies in wearable sensors

APL Bioengineering, Journal Year: 2023, Volume and Issue: 7(2)

Published: May 31, 2023

This Editorial highlights some current challenges and emerging solutions in wearable sensors, a maturing field where interdisciplinary crosstalk is of paramount importance. Currently, investigation efforts are aimed at expanding the application scenarios translating early developments from basic research to widespread adoption personal health monitoring for diagnostic therapeutic purposes. translation requires addressing several old new that summarized this editorial. The special issue "Emerging technologies sensors" includes four selected contributions leading researchers, exploring topic different perspectives. aim provide APL Bioengineering readers with solid timely overall vision recent examples avenues.

Language: Английский

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Sustainable, Wearable, and Eco‐Friendly Electronic Textiles

Energy & environment materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Wearable electronic textiles (e‐textiles) with embedded electronics offer promising solutions for unobtrusive, real‐time health monitoring, enhancing healthcare efficiency. However, their adoption is limited by performance and sustainability challenges in materials, manufacturing, recycling. This study introduces a sustainable paradigm the fabrication of fully inkjet‐printed Smart, Wearable, Eco‐friendly Electronic Textiles (SWEET) first comprehensive assessments biodegradability life cycle assessment (LCA). SWEET addresses existing limitations, enabling concurrent continuous monitoring human physiology, including skin surface temperature (at coefficient resistance, TCR value ~−4.4% °C −1 ) heart rate (~74 beats per minute, bpm) separately simultaneously like industry gold standard, using consistent, versatile, highly efficient graphene Poly (3,4‐ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT:PSS)‐based wearable e‐textiles. Demonstrations garment on five participants confirm system's capability to monitor electrocardiogram (ECG) signals temperature. Such biodegradable e‐textiles decompose ~48% weight lost ~98% strength over 4 months. Life (LCA) reveals that graphene‐based electrode has lowest climate change impact ~0.037 kg CO 2 eq, 40 times lower than reference electrodes. approach material manufacturing challenges, while aligning environmental responsibility, marking significant leap forward e‐textile technology personalized management.

Language: Английский

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Direct-Ink Writing Processing of High-k Poly(vinylidene fluoride-trifluoroethylene-chlorofluoroethylene) and Its Integration into an All-Printed Capacitive Touch-Sensing Device

ACS Applied Electronic Materials, Journal Year: 2023, Volume and Issue: 5(11), P. 5977 - 5985

Published: Oct. 20, 2023

Direct-ink writing (DIW) printing technology represents a suitable and efficient additive manufacturing technique for producing intricate designs structures directly on the application surface. This work has demonstrated potential of combining DIW screen to fabricate an all-printed 7 × capacitive touch sensor based high dielectric constant (high-k) poly(vinylidene fluoride-trifluoroethylene-chlorofluoroethylene)─P(VDF-TrFE-CFE). The printed device allows maximum detection signal-to-noise ratio (SNR) 20 dB, large sensitivity that demonstrates sensor's ability detect respond precisely user input. Furthermore, by demonstrating processability P(VDF-TrFE-CFE) with printing, this research also opens way low-cost fabrication integration sensing devices polymer.

Language: Английский

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Tuning Microelectrodes’ Impedance to Improve Fast Ripples Recording

Bioengineering, Journal Year: 2024, Volume and Issue: 11(1), P. 102 - 102

Published: Jan. 22, 2024

Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal neuronal hyperexcitability. In the case of pharmacoresistant epilepsy requiring resection surgery, identification Epileptogenic Zone (EZ) critical. Fast Ripples (FRs; 200–600 Hz) are one promising biomarkers that can aid in EZ delineation. However, recording FRs requires physically small electrodes. These microelectrodes suffer high impedance, which significantly impacts FRs’ observability and detection. this study, we investigated potential conductive polymer coating to enhance FR observability. We employed biophysical modeling compare two types microelectrodes: Gold (Au) Au coated with poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (Au/PEDOT:PSS). electrodes were then implanted into CA1 hippocampal neural network epileptic mice record during epileptogenesis. The results showed polymer-coated had two-order lower impedance as well higher transfer function amplitude cut-off frequency. Consequently, recorded PEDOT:PSS-coated microelectrode yielded signal energy compared uncoated one. PEDOT:PSS improved thus their This work paves way for development signal-specific designs allow better targeting pathological biomarkers.

Language: Английский

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Inkjet-printed transparent electrodes for electrical brain stimulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

ABSTRACT Electrical stimulation is a powerful tool for investigating and modulating brain activity, as well treating neurological disorders. However, understanding the precise effects of electrical on neural activity has been hindered by limitations in recording neuronal responses near stimulating electrode, such artifacts electrophysiology or obstruction field view imaging. In this study, we introduce novel device fabricated from conductive polymers that transparent therefore compatible with optical imaging techniques. The manufactured using combination microfabrication inkjet printing techniques flexible, allowing better adherence to brain’s natural curvature. We characterized properties electrode evaluated its performance an anesthetized mouse. Furthermore, combined experimental data finite-element model in-vivo setup estimate maximum electric highly can generate mouse brain. Our findings indicate high 300 V/m, demonstrating potential studying manipulating range relevant human applications. Overall, work presents promising approach developing versatile new tools apply study stimulation.

Language: Английский

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