Paper-based microfluidics: Analyte-driven imbibition under the lens DOI
Sumit Kumar Mehta,

Shubham Kumar,

Amy Q. Shen

et al.

Biomicrofluidics, Journal Year: 2025, Volume and Issue: 19(3)

Published: May 1, 2025

Paper-based microfluidic devices are widely used in point-of-care diagnostics, yet the fundamental mechanisms governing analyte transport under partially saturated conditions remain insufficiently characterized. Here, we systematically investigate concentration-dependent imbibition dynamics and particle trapping behavior of analyte/colloid-laden fluids porous paper substrates. Using model food-dye colloids varying sizes (∼0.3–4.5 μm) concentrations (0.5–2 mg/ml), quantify key saturation-dependent parameters reveal their strong influence on wicking length retention. A semiempirical numerical incorporating experimentally derived van Genuchten Brooks–Corey is developed to predict flow conditions. Our study demonstrates that size, concentration, properties critically modulate behavior, with implications for reproducibility sensitivity lateral assays. Furthermore, through Damköhler number analysis, propose practical design guidelines optimal test line placement based reaction dynamics. This combined experimental modeling framework offers new insights rational optimization paper-based diagnostic platforms.

Language: Английский

Nanomaterials-driven paper-based biosensors for food contaminants detection: Classification, mechanism and applications DOI
Yang Song, Xiaoyun Xu, Hengyi Xu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 532, P. 216512 - 216512

Published: Feb. 18, 2025

Language: Английский

Citations

5
Integration of microfluidic chips with biosensors DOI Creative Commons

Masindi Sekhwama,

Kelvin Mpofu,

Sivarasu Sudesh

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(9)

Published: Aug. 23, 2024

Abstract The potential threat posed by disease outbreaks to diagnostic instruments demands the development of more effective biosensor technologies counteract risks. Diseases like SARS-CoV-2, Ebola, malaria, cholera, and many have demonstrated beyond limits health care that new advancements are required for early detection diagnosis. rising number diseases has led an increasing demand biosensors quicker utilize in healthcare settings. A incorporated with microfluidic chips offers improved compared traditional or classical biosensors. Microfluidic improve performance allowing automation, mixing, separation, throughput processing, transport analytes desired reactors. a chip sensitivity, easy operation can use small volumes samples process results. effectiveness depends also on materials used its fabrication there which reviewed this work. This paper reviews advantages enhance biosensors, fabricate chips, electrodes into time shortening processing at point service. work not previously addressed other including, integration cell-imprinted polymers sensors delved future outlook.

Language: Английский

Citations

12
Paper-based biosensing using single-stranded oligonucleotide aptamers for enhanced food safety DOI Creative Commons

Kiyana Fatemi,

Sie Yon Lau,

Reza Fatemi

et al.

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107331 - 107331

Published: Feb. 1, 2025

Language: Английский

Citations

2
Navigating pharmaceuticals: microfluidic devices in analytical and formulation sciences DOI Creative Commons

Ankita Das,

Parixit Prajapati

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: March 22, 2025

Language: Английский

Citations

1
Advancements and challenges in microfluidic paper-based analytical devices: design, manufacturing, sustainability, and field applications DOI Creative Commons
Prakash Aryal, Charles S. Henry

Frontiers in Lab on a Chip Technologies, Journal Year: 2024, Volume and Issue: 3

Published: Dec. 20, 2024

Microfluidic paper-based analytical devices (µPADs) have gained significant attention in science and technology due to their numerous advantages over traditional techniques, including cost-effectiveness, miniaturization, sustainability. µPADs are widely used point-of-care diagnostics, health monitoring, environmental detection, food safety, forensics, security. Since the first report 2007, there been substantial advancements fabrication detection methods, applications. Over years, efforts made improve manufacturing scalability, user-friendliness, sustainability of µPADs. In this review, we explore general trends fabrication, sensing applications µPADs, highlighting key improvements innovations. We also examine eco-friendliness present real-world success stories from field studies citizen initiatives. Additionally, address challenges associated with transitioning lab field. Finally, outlook for propose strategies usefulness various fields.

Language: Английский

Citations

6
Nano-engineered fiber-based sensing frontiers: Revolutionizing on-site pesticide detection for global food-environment nexus challenges DOI
An Du, Hua Li,

Zizhao Guo

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216710 - 216710

Published: April 18, 2025

Language: Английский

Citations

0
Paper-based microfluidics: Analyte-driven imbibition under the lens DOI
Sumit Kumar Mehta,

Shubham Kumar,

Amy Q. Shen

et al.

Biomicrofluidics, Journal Year: 2025, Volume and Issue: 19(3)

Published: May 1, 2025

Paper-based microfluidic devices are widely used in point-of-care diagnostics, yet the fundamental mechanisms governing analyte transport under partially saturated conditions remain insufficiently characterized. Here, we systematically investigate concentration-dependent imbibition dynamics and particle trapping behavior of analyte/colloid-laden fluids porous paper substrates. Using model food-dye colloids varying sizes (∼0.3–4.5 μm) concentrations (0.5–2 mg/ml), quantify key saturation-dependent parameters reveal their strong influence on wicking length retention. A semiempirical numerical incorporating experimentally derived van Genuchten Brooks–Corey is developed to predict flow conditions. Our study demonstrates that size, concentration, properties critically modulate behavior, with implications for reproducibility sensitivity lateral assays. Furthermore, through Damköhler number analysis, propose practical design guidelines optimal test line placement based reaction dynamics. This combined experimental modeling framework offers new insights rational optimization paper-based diagnostic platforms.

Language: Английский

Citations

0