Fluctuating Chromatin Facilitates Enhancer–Promoter Communication by Regulating Transcriptional Clustering Dynamics DOI

Tao Zhu,

Chunhe Li, Xiakun Chu

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(45), P. 11428 - 11436

Published: Nov. 7, 2024

Enhancers regulate gene expression by forming contacts with distant promoters. Phase-separated condensates or clusters formed transcription factors (TFs) and cofactors are thought to facilitate these enhancer-promoter (E-P) interactions. Using polymer physics, we developed distinct coarse-grained chromatin models that produce similar ensemble-averaged Hi-C maps but "stable" "dynamic" characteristics. Our findings, consistent recent experiments, reveal a multistep E-P communication process. The dynamic model facilitates proximity enhancing TF clustering subsequently promotes direct interactions destabilizing the through chain flexibility. study physical understanding of molecular mechanisms governing in transcriptional regulation.

Language: Английский

Fluctuating Chromatin Facilitates Enhancer–Promoter Communication by Regulating Transcriptional Clustering Dynamics DOI

Tao Zhu,

Chunhe Li, Xiakun Chu

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(45), P. 11428 - 11436

Published: Nov. 7, 2024

Enhancers regulate gene expression by forming contacts with distant promoters. Phase-separated condensates or clusters formed transcription factors (TFs) and cofactors are thought to facilitate these enhancer-promoter (E-P) interactions. Using polymer physics, we developed distinct coarse-grained chromatin models that produce similar ensemble-averaged Hi-C maps but "stable" "dynamic" characteristics. Our findings, consistent recent experiments, reveal a multistep E-P communication process. The dynamic model facilitates proximity enhancing TF clustering subsequently promotes direct interactions destabilizing the through chain flexibility. study physical understanding of molecular mechanisms governing in transcriptional regulation.

Language: Английский

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