Reversible Swell–Shrink Hydrogel Microspheres for High-Selectivity Digital SERS Analysis of Nonvolatile Fentanyl in Simulated Breath Aerosols
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
In
clinical
diagnostics,
human
breath
presents
an
alternative
and
more
convenient
sample
than
biofluids
for
detecting
the
ingestion
of
nonvolatile
drugs.
Surface-enhanced
Raman
spectroscopy
(SERS)
is
a
powerful
vibrational
technique
with
high
sensitivity
based
on
molecular
fingerprinting.
However,
low
affinity
traditional
SERS
substrates
aerosols
stochastic
fluctuation
signal
at
concentrations
limit
their
application
in
aerosol
analysis.
this
study,
we
synthesized
hydrogel
microsphere
highly
reversible
swelling/shrinking
properties
that
enhance
target
analyte
accumulation
promote
plasmonic
nanoparticle
aggregation
intense
hotspot
formation.
Furthermore,
these
function
as
three-in-one
system,
enabling
multilevel
selectivity
size,
charge,
hydrophilicity
molecules
simultaneously
without
pretreatment.
Notably,
by
"digitizing"
each
individual
calculating
proportion
positive
microspheres,
microspheres
can
serve
digital
platform
circumvents
stability
issues
resulting
from
fluctuations
intensity.
Consequently,
achieved
detection
0.5
ppm
fentanyl
simulated
aerosols.
This
innovative
sensing
strategy
not
only
demonstrates
promising
approach
screening
drugs
but
also
simplifies
sampling
process,
holding
great
potential
diagnosis
Language: Английский
Personalized air exhaust combined with mixing ventilation for environmental management and airborne droplets in a train cabin
Renze Xu,
No information about this author
Fan Wu,
No information about this author
Lian Shen
No information about this author
et al.
Physics of Fluids,
Journal Year:
2025,
Volume and Issue:
37(3)
Published: March 1, 2025
The
enclosed
space
and
high
passenger
density
in
high-speed
train
cabins
pose
substantial
challenges
providing
a
safe,
healthy,
comfortable
indoor
environment,
especially
during
pandemics
such
as
COVID-19
influenza.
High
ventilation
rates,
while
beneficial
reducing
pathogen
transmission,
may
compromise
airflow
field
quality
result
great
energy
consumption.
Therefore,
understanding
the
tradeoffs
between
transmission
risk,
thermal
comfort,
saving
is
critical
for
devising
cabin
systems.
As
primary
method
of
regulating
environments,
heating,
ventilation,
air
conditioning
systems
are
central
to
this
study,
which
proposes
an
improved
personalized
mode
that
combines
exhaust
with
various
supply
strategies.
results
indicate
considerably
reduces
longitudinal
spread
particles
rapidly
decreases
their
concentration
air.
When
paired
higher
proportion
entering
through
sidewall
outlets,
primarily
diffuses
upward.
proposed
enhances
balances
consumption
quality,
delivers
significant
performance
improvements,
including
22.4%
increase
utilization
efficiency
over
23.3%
reduction
suspended
droplets.
This
study
provides
theoretical
foundation
optimizing
post-pandemic
era.
Language: Английский