Polymer models of chromatin organization in virally infected cells DOI Creative Commons

Andrea Fontana,

Fabrizio Tafuri,

Alex Abraham

et al.

Biochemical Society Transactions, Journal Year: 2025, Volume and Issue: 53(01)

Published: Feb. 7, 2025

Genome architecture is closely tied to essential biological functions, yet a complete understanding of the mechanisms governing DNA folding remains significant challenge. Theoretical models based on polymer physics have been applied decipher complexity chromatin and uncover physical processes shaping its structure. Importantly, recent findings suggest that certain viruses can alter 3D organization host genome. In this review, we highlight advances in development used study how structure within cell re-organizes following viral infection, with particular emphasis SARS-CoV-2 virus, capable altering genome at different scales, including A/B compartments, TADs gene-enhancer regulatory contacts.

Language: Английский

Polymer models of chromatin organization in virally infected cells DOI Creative Commons

Andrea Fontana,

Fabrizio Tafuri,

Alex Abraham

et al.

Biochemical Society Transactions, Journal Year: 2025, Volume and Issue: 53(01)

Published: Feb. 7, 2025

Genome architecture is closely tied to essential biological functions, yet a complete understanding of the mechanisms governing DNA folding remains significant challenge. Theoretical models based on polymer physics have been applied decipher complexity chromatin and uncover physical processes shaping its structure. Importantly, recent findings suggest that certain viruses can alter 3D organization host genome. In this review, we highlight advances in development used study how structure within cell re-organizes following viral infection, with particular emphasis SARS-CoV-2 virus, capable altering genome at different scales, including A/B compartments, TADs gene-enhancer regulatory contacts.

Language: Английский

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