Designing Stable Macroporous Hydrogels: Effects of Single and Dual Surfactant Systems on Porous Architecture, Absorption Capacity, and Mechanical Strength

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Comparison of Wound Healing Effects of Different Micro-Patterned Hydrogels on the Skin of Secondary Intention Rat Model

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 239 - 239

Published: March 24, 2025

Background: The skin acts as a barrier against external threats, and moisture is crucial for effective wound healing, it promotes epithelial cell migration. Thus, high water content supports healing by maintaining moisture, absorbing exudate, forming protective barrier. Here, we created three different micro-patterned hydrogels tested them on rat wounds. Materials Methods: Three (waves, lines, checks) hydrogel patches were using three-dimensional polymer networks. On SD skin, wounds making incisions, the applied. rats divided into experimental groups based micro-patterns. Rats without (vehicle) those with flat (no shape) considered controls. closure rate (WCR) was calculated, expression of Col1A protein measured western blot. Results: After 7 days, WCR significantly higher in treated compared to vehicle no-shape groups. Specifically, highest checks group waves lines Furthermore, evaluated at days 14, revealing significant increase after 14 Conclusions: demonstrated superior efficacy, indicated increased days. These findings highlight importance pattern design improving suggesting that optimized micro-patterns can enhance therapeutic outcomes management.

Language: Английский

Multifunctional Dual-Layer Microneedles Loaded with Selenium-Doped Carbon Quantum Dots and Astilbin for Ameliorating Diabetic Wound Healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101739 - 101739

Published: April 1, 2025

Language: Английский