Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels DOI Creative Commons
Yuhao Deng, Song Chen, Tuerxun Maimaitiaili

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 21, 2025

Infected bone defects represent one of the most prevalent clinical conditions, affecting millions patients annually. The local infection and necrosis associated with these exacerbate injury, prolong healing times, result in significant localized pain, presenting a substantial challenge for repair. In this study, we developed biomimetic mineralized antibacterial imCOL1MA hydrogel by employing methacrylated COL1, composite native inorganic salts (CNBIS), Magainin II-PLGA microspheres (mMicrospheres), which was further loaded marrow stem cells (BMSCs) to form osteogenic engineered infected Briefly, first optimized concentration COL1MA BMSCs survival, then adjusted proportion CNBIS create an appropriate osteoinductive microenvironment, encapsulated II poly (lactic-co-glycolic acid) (PLGA) microsphere long-term antimicrobial function. Consequently, promising prepared using 10% COL1MA, 2% CNBIS, 1% mMicrospheres. scaffold served as efficacy, excellent biodegradability, good biocompatibility, microenvironment. As result, could achieve rapid (only 4 weeks) vascularized neuralized regeneration rabbit model defects.

Language: Английский

Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels DOI Creative Commons
Yuhao Deng, Song Chen, Tuerxun Maimaitiaili

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 21, 2025

Infected bone defects represent one of the most prevalent clinical conditions, affecting millions patients annually. The local infection and necrosis associated with these exacerbate injury, prolong healing times, result in significant localized pain, presenting a substantial challenge for repair. In this study, we developed biomimetic mineralized antibacterial imCOL1MA hydrogel by employing methacrylated COL1, composite native inorganic salts (CNBIS), Magainin II-PLGA microspheres (mMicrospheres), which was further loaded marrow stem cells (BMSCs) to form osteogenic engineered infected Briefly, first optimized concentration COL1MA BMSCs survival, then adjusted proportion CNBIS create an appropriate osteoinductive microenvironment, encapsulated II poly (lactic-co-glycolic acid) (PLGA) microsphere long-term antimicrobial function. Consequently, promising prepared using 10% COL1MA, 2% CNBIS, 1% mMicrospheres. scaffold served as efficacy, excellent biodegradability, good biocompatibility, microenvironment. As result, could achieve rapid (only 4 weeks) vascularized neuralized regeneration rabbit model defects.

Language: Английский

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