Autophagy and the cell biology of age-related disease

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(12), P. 1338 - 1348

Published: Nov. 16, 2018

Language: Английский

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Exercise Attenuates the Major Hallmarks of Aging

Rejuvenation Research, Journal Year: 2014, Volume and Issue: 18(1), P. 57 - 89

Published: Nov. 28, 2014

Regular exercise has multi-system anti-aging effects. Here we summarize how impacts the major hallmarks of aging. We propose that, besides searching for novel pharmaceutical targets aging process, more research efforts should be devoted to gaining insights into molecular mediators benefits and implement effective interventions elderly people.

Language: Английский

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Chemical modulators of autophagy as biological probes and potential therapeutics

Nature Chemical Biology, Journal Year: 2010, Volume and Issue: 7(1), P. 9 - 17

Published: Dec. 16, 2010

Language: Английский

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Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Biochemical Society Transactions, Journal Year: 2013, Volume and Issue: 41(5), P. 1103 - 1130

Published: Sept. 23, 2013

Autophagy is an intracellular degradation pathway essential for cellular and energy homoeostasis. It functions in the clearance of misfolded proteins damaged organelles, as well recycling cytosolic components during starvation to compensate nutrient deprivation. This process regulated by mTOR (mammalian target rapamycin)-dependent mTOR-independent pathways that are amenable chemical perturbations. Several small molecules modulating autophagy have been identified potential therapeutic application diverse human diseases, including neurodegeneration. Neurodegeneration-associated aggregation-prone predominantly degraded therefore stimulating this with inducers beneficial a wide range transgenic disease models. Emerging evidence indicates compromised contributes aetiology various neurodegenerative diseases related protein conformational disorders causing accumulation mutant toxicity. Combining knowledge dysfunction mechanism drug action may thus be rational designing targeted therapy. The present review describes signalling regulating mammalian highlights disorders.

Language: Английский

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Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(8), P. 553 - 571

Published: July 15, 2020

Language: Английский

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